Most Read Articles
Pearl Toh, 15 Feb 2019
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
30 Nov 2018
Poor adherence to statin therapy is leaving many patients with dyslipidaemia at high risk of potentially life-threatening cardiovascular events. Statins are the current standard of care for reducing the risk of cardiovascular disease in these patients and for improving life expectancy, with possible economic benefits for healthcare systems too. However, many patients with dyslipidaemia are not achieving or maintaining treatment targets because they fail to stick to their prescribed statin therapy. An article co-authored by lipidologist Peter Lansberg, and published in Vascular Health and Risk Management, considers this issue and reviews approaches to overcome non-adherence.

Delayed heart rate recovery after exercise ups risk of MetS in men

08 Feb 2019

A lowered autonomic function, measured as the delayed heart rate recovery (HRR) after exercise, increases the risk of cardiometabolic syndrome (MetS) in otherwise healthy men, reports a new study.

Researchers enrolled 2,740 men (mean age 47.7 years) who had no evidence of MetS, cardiovascular disease, hypertension and diabetes at baseline. Participants were asked to perform peak treadmill exercise testing. This was followed by a recovery protocol consisting of a 2-minute slow walking without incline, during which HRR was calculated.

After a mean follow-up period of 5 years, 845 developed MetS while 1,895 did not. The resulting incidence rate of MetS was 61 per 1,000 person-years. Those who developed MetS tended to have higher body mass index and waist girth (p<0.001 for both).

Categorizing the participants according to quartiles of 1-minute HRR, researchers found that those in the lowest vs highest quartile were significantly more likely to develop MetS. This relationship remained significant even after adjusting for confounders such as body mass index, uric acid, smoking and alcohol intake (relative risk [RR], 1.24; 95 percent CI, 1.02–1.51).

Results were more pronounced when 2-minute HRR was used (first vs fourth quartile: RR, 2.02; 1.58–2.60). In contrast, when HRR was taken as a continuous variable, no significant correlations were observed (1-minute: RR, 0.99; 0.98–1.00; 2-minute: RR, 0.98; 0.97–0.99).

The present findings suggest that a delay in HRR after exercise testing increases the risk of incident MetS, independent of important confounders such as oxygen uptake and resting heart rate, said researchers.

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Most Read Articles
Pearl Toh, 15 Feb 2019
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
30 Nov 2018
Poor adherence to statin therapy is leaving many patients with dyslipidaemia at high risk of potentially life-threatening cardiovascular events. Statins are the current standard of care for reducing the risk of cardiovascular disease in these patients and for improving life expectancy, with possible economic benefits for healthcare systems too. However, many patients with dyslipidaemia are not achieving or maintaining treatment targets because they fail to stick to their prescribed statin therapy. An article co-authored by lipidologist Peter Lansberg, and published in Vascular Health and Risk Management, considers this issue and reviews approaches to overcome non-adherence.