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Tristan Manalac, 18 Nov 2020
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Delayed decompression ups mortality risk in UTI patients with stones

16 Nov 2020

Overall mortality risk is low in patients with obstructing upper urinary tract stones and urinary tract infection, but a delay in decompression is associated with an increased likelihood of death, results of a study have shown.

“Obstructive pyelonephritis is considered a urological emergency, but there is limited evidence regarding the importance of prompt decompression,” the investigators said.

This study aimed at determining whether delay in decompression was independently predictive of in-hospital mortality, as well as the impact of patient, hospital, and disease factors on the probability of receipt of delayed vs prompt decompression.

A total of 311,100 patients aged 18 years with ICD-9 diagnosis of urinary tract infection who had either a ureteral stone or kidney stone with hydronephrosis were identified using the National Inpatient Sample from 2010 to 2015. Weighted sample multivariate logistic regression models were generated to assess the predictors of death in the hospital and of delayed decompression (2 days after admission).

Delayed decompression significantly heightened the risk of death by 29 percent (odds ratio [OR], 1.29, 95 percent confidence interval [CI], 1.03–1.63; p=0.032) and was more likely to occur with weekend admissions (OR, 1.22, 95 percent CI, 1.15–1.30; p<0.001), nonwhite race (OR, 1.34, 95 percent CI, 1.25–1.44; p<0.001), and lower income demographic (lowest income quartile OR, 1.25, 95 percent CI, 1.14–1.36; p<0.001).

“The increased likelihood of delay associated with weekend admissions, minority patients, and lower socioeconomic status suggests opportunities for improvement,” the investigators said.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).