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Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
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Delayed breast reconstruction is best for women requiring radiotherapy

03 Nov 2019

Radiotherapy may partly account for adverse long-term flap-related outcomes following immediate breast reconstruction (IBR), a recent study has shown.

Researchers retrospectively assessed 1,247 women who underwent autologous breast reconstruction between August 1997 and October 2013. Patients who received IBR with postmastectomy radiotherapy (PMRT; n=20; mean age, 46.25 years) were matched to two others who opted for delayed breast reconstruction (DBR) after PMRT (n=40; mean age, 46.08 years). Outcomes included early and late complications.

There were two cases of flap revision, both occurring in DBR group. These were ultimately successful, such that no flap failures were reported for either group. The incidence rates of early complications were comparable between the DBR and IBR arms.

In terms of long-term complications, 60 percent (n=12) of the IBR group developed contractures. In comparison, only 2.5 percent of the DBR group experienced fibrosis. The resulting between-group difference was significant (p<0.001).

A similar trend was reported for fat necrosis, which occurred in 60 percent of the IBR group and in only 12.5 percent of the DBR group (p<0.001).

“[W]hen the intent is to provide curative treatment, the choice between IBR and DBR is often determined by the need for PMRT,” the researchers explained. “Due to the adverse effects of radiotherapy on the reconstruction, the consensus is to postpone the reconstruction until after completion of adjuvant radiotherapy.”

Moreover, even in cases where patients specifically request for immediate reconstruction, clinicians should nevertheless inform them of the associated risks of the procedure, they added.

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Most Read Articles
Roshini Claire Anthony, Yesterday

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

6 days ago
Men who undergo flexible cystoscopy, particularly with a longer dwell time, may benefit from intraurethral lidocaine as it provides significant pain reduction, suggest the results of a meta-analysis. Evidence is lacking for other tested interventions.
Tristan Manalac, 2 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 5 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.