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Elvira Manzano, Yesterday
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, Yesterday
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Jairia Dela Cruz, 16 Sep 2020
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Pearl Toh, 21 Sep 2020
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Delayed breast reconstruction is best for women requiring radiotherapy

03 Nov 2019

Radiotherapy may partly account for adverse long-term flap-related outcomes following immediate breast reconstruction (IBR), a recent study has shown.

Researchers retrospectively assessed 1,247 women who underwent autologous breast reconstruction between August 1997 and October 2013. Patients who received IBR with postmastectomy radiotherapy (PMRT; n=20; mean age, 46.25 years) were matched to two others who opted for delayed breast reconstruction (DBR) after PMRT (n=40; mean age, 46.08 years). Outcomes included early and late complications.

There were two cases of flap revision, both occurring in DBR group. These were ultimately successful, such that no flap failures were reported for either group. The incidence rates of early complications were comparable between the DBR and IBR arms.

In terms of long-term complications, 60 percent (n=12) of the IBR group developed contractures. In comparison, only 2.5 percent of the DBR group experienced fibrosis. The resulting between-group difference was significant (p<0.001).

A similar trend was reported for fat necrosis, which occurred in 60 percent of the IBR group and in only 12.5 percent of the DBR group (p<0.001).

“[W]hen the intent is to provide curative treatment, the choice between IBR and DBR is often determined by the need for PMRT,” the researchers explained. “Due to the adverse effects of radiotherapy on the reconstruction, the consensus is to postpone the reconstruction until after completion of adjuvant radiotherapy.”

Moreover, even in cases where patients specifically request for immediate reconstruction, clinicians should nevertheless inform them of the associated risks of the procedure, they added.

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Most Read Articles
Elvira Manzano, Yesterday
Monthly injections of the PCSK9* monoclonal antibody evolocumab effectively reduced plasma LDL-cholesterol (LDL-C), often referred to as the bad cholesterol, in teenagers with heterozygous familial hypercholesterolaemia (HeFH) already taking statins, with or without ezetimibe, the HAUSER-RCT has shown.
Jairia Dela Cruz, Yesterday
For individual with type 2 diabetes, losing weight is everything when it comes to improving the metabolic function, and it matters little whether this is achieved by dieting or undergoing bariatric surgery, according to a small study.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.