Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.

Deep remission in early Crohn’s disease cuts risk of progression

17 Apr 2020

Inducing deep remission in patients with early, moderate-to-severe Crohn’s disease (CD) leads to a lower risk of progression, regardless of management strategy, according to a study.

The analysis involved 122 patients (mean age, 31.2 years) with moderate-to-severe CD (median duration, 0.2 years) who participated in the effect of tight control management on CD (CALM) study. Of these patients, 61 were assigned to a tight control strategy (increased therapy based on faecal level of calprotectin, serum level of C-reactive protein, and symptoms) and the other half were assigned to conventional management.

Researchers examined the association of deep remission with the primary endpoint, which was a composite of major adverse outcomes indicating CD progression during the follow-up period (median, 3.02 years), as follows: new internal fistulas or abscesses, strictures, perianal fistulas or abscesses, or hospitalization or surgery for CD. Deep remission was defined as CD endoscopic index of severity scores <4, with no deep ulcerations or steroid treatment, for ≥8 weeks.

Over a median follow-up of 3.02 years, major adverse outcomes occurred in 34 patients (27.9 percent) during the follow-up period. Significantly fewer patients who did vs did not achieve deep remission at the end of the CALM study had the said outcomes (p=0.01).

Multivariable Cox regression analysis confirmed the association between deep remission and a lower risk of major adverse outcome (adjusted hazard ratio, 0.19, 95 percent confidence interval, 0.07–0.31).

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Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.