Most Read Articles
06 Jun 2019
Treatment with probiotics falls short of improving gastrointestinal (GI) symptoms in patients with systemic sclerosis, a study has shown.
11 May 2020
A number of patients with coronavirus disease 2019 (COVID-19) present with diarrhoea, and this group may suffer discomfort longer and show persistent positive SARS-CoV-2 in stool specimens as compared with patients who do not have the symptom, as shown in a study.
Stephen Padilla, 28 Oct 2019
Any manner of early postoperative diet delivered into the gastrointestinal tract (GIT) following colorectal surgery will help stimulate gut motility, leading to an earlier return of bowel function and a shorter length of hospital stay (LOS), according to a systematic review and meta-analysis.
11 May 2020
Antireflux surgery results in improved quality of life (QOL) and reduced oesophageal acid exposure in neurologically normal (NN) and impaired (NI) children in the short and medium term, according to the results of a systematic review.

Deep remission in early Crohn’s disease cuts risk of progression

17 Apr 2020

Inducing deep remission in patients with early, moderate-to-severe Crohn’s disease (CD) leads to a lower risk of progression, regardless of management strategy, according to a study.

The analysis involved 122 patients (mean age, 31.2 years) with moderate-to-severe CD (median duration, 0.2 years) who participated in the effect of tight control management on CD (CALM) study. Of these patients, 61 were assigned to a tight control strategy (increased therapy based on faecal level of calprotectin, serum level of C-reactive protein, and symptoms) and the other half were assigned to conventional management.

Researchers examined the association of deep remission with the primary endpoint, which was a composite of major adverse outcomes indicating CD progression during the follow-up period (median, 3.02 years), as follows: new internal fistulas or abscesses, strictures, perianal fistulas or abscesses, or hospitalization or surgery for CD. Deep remission was defined as CD endoscopic index of severity scores <4, with no deep ulcerations or steroid treatment, for ≥8 weeks.

Over a median follow-up of 3.02 years, major adverse outcomes occurred in 34 patients (27.9 percent) during the follow-up period. Significantly fewer patients who did vs did not achieve deep remission at the end of the CALM study had the said outcomes (p=0.01).

Multivariable Cox regression analysis confirmed the association between deep remission and a lower risk of major adverse outcome (adjusted hazard ratio, 0.19, 95 percent confidence interval, 0.07–0.31).

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Most Read Articles
06 Jun 2019
Treatment with probiotics falls short of improving gastrointestinal (GI) symptoms in patients with systemic sclerosis, a study has shown.
11 May 2020
A number of patients with coronavirus disease 2019 (COVID-19) present with diarrhoea, and this group may suffer discomfort longer and show persistent positive SARS-CoV-2 in stool specimens as compared with patients who do not have the symptom, as shown in a study.
Stephen Padilla, 28 Oct 2019
Any manner of early postoperative diet delivered into the gastrointestinal tract (GIT) following colorectal surgery will help stimulate gut motility, leading to an earlier return of bowel function and a shorter length of hospital stay (LOS), according to a systematic review and meta-analysis.
11 May 2020
Antireflux surgery results in improved quality of life (QOL) and reduced oesophageal acid exposure in neurologically normal (NN) and impaired (NI) children in the short and medium term, according to the results of a systematic review.