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Roshini Claire Anthony, 28 Jan 2020

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Decreased insulin sensitivity, β-cell compensation characterize NODAP

23 Jan 2020

Individuals with new-onset prediabetes/diabetes after non-necrotizing acute pancreatitis (NODAP) more often have reduced insulin sensitivity, β-cell compensation, and no significant change in postprandial levels of glucagon and pancreatic polypeptide, suggests a study.

Twenty-nine individuals with NODAP and 29 age- and sex-matched healthy controls were included. After fasting for at least 8 h, participants received 12 oz of BOOST drink. Their blood samples were collected before and after stimulation to measure insulin, C-peptide, glucagon and pancreatic polypeptide.

The authors calculated the indices of insulin sensitivity (HOMA-IS, 1/fasting insulin, Raynaud and Matsuda) and insulin secretion (HOMA-β, Stumvoll, insulinogenic index 30’ and 60’). Repeated measures analyses were performed in both unadjusted and adjusted models.

Individuals with NODAP had significantly higher insulin and C-peptide levels than controls during mixed meal test in both unadjusted (p-both=0.001) and adjusted models (p=0.004 and p=0.006, respectively). Those with NODAP also had significantly higher HOMA-β (p=0.028) and Stumvoll index (p=0.013) but significantly lower HOMA-IS (p=0.005), 1/fasting insulin (p=0.018), Raynaud index (p=0.018) and Matsuda index (p=0.021).

No significant differences were observed in glucagon and pancreatic polypeptide levels between NODAP and controls during mixed meal test in both the unadjusted (p=0.345 and p=0.206, respectively) and adjusted models (p=0.359 and p=0.158, respectively).

“The above findings may help develop an evidence-based protocol with a view to optimize control of glucose homeostasis in NODAP,” the authors said.

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Most Read Articles
Roshini Claire Anthony, 28 Jan 2020

Individuals with type 2 diabetes (T2D) who are prescribed an SGLT2* inhibitor may have a reduced risk for developing gout compared with those who are prescribed a GLP-1** receptor agonist, according to a study from the US.

Jairia Dela Cruz, 27 Jan 2020
Bariatric surgery is beneficial to nondiabetic Asian patients with obesity, delivering sustained weight loss in addition to normalizing sugar levels and insulin resistance within 1–3 years of the procedure, as reported in a Singapore study.
2 days ago
Sleep disorder in nonstandard shift workers appears to contribute to more severe hypogonadal symptoms and lower testosterone levels when compared with daytime workers and nonstandard shift workers without sleep disorder, according to a study.
12 Nov 2019
Markedly different blood glucose responses and postexercise profiles are associated with fasting morning resistance exercise (RE) compared with afternoon RE in individuals with type 1 diabetes (T1D), a recent study has shown.