Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Decline in mammographic density greatest during menopause

17 Jul 2017

Age-associated declines in mammographic density (MD), while occurring pre- and postmenopausally, are most pronounced during menopause, a new study reports.

This trend is consistent worldwide and across a wide variety of ethnic and geographical groups suggesting an underlying innate biological mechanism.

Analysis of 11,423 women (35 to 85 years of age) showed that postmenopausal women had lower percent MD (PD; difference, -0.46 cm; 95 percent CI, -0.53 to -0.39) and lower dense area (difference, -0.55 cm; -0.65 to -0.45) compared with premenopausal women of the same age.

On the other hand, nondense area (difference, 0.32 cm; 0.21 to 0.43) was larger in postmenopausal women than in premenopausal women of the same age.

In premenopausal women, every 10-year increase in age was associated with decreases in PD (difference, -0.24; -0.34 to -0.14) and dense area (difference, -0.27; -0.41 to -0.14). Changes in PD and dense area were not associated with changes in breast area.

PD (difference, -0.38; -0.44 to -0.33) and dense area (difference, -0.32; -0.39 to -0.24) also decreased in postmenopausal women with every 10-year increase in age. In contrast to premenopausal women, a corresponding increase in breast area (difference, 0.34; 0.24 to 0.39) was observed in postmenopausal women.

While there were variations in the trend when the women were grouped according to reproductive factors (parity and age at first birth), there were no significant variations across the different ethnic groups except for larger decreases in PD in Malay and South Asian women.

Information was retrieved from the International Consortium on Mammographic Density. Participants were free of breast cancer and were categorized as pre- (n=4,534) or postmenopausal (n=6,481). MD was measured using the Cumulus method.

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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.