Most Read Articles
Jenny Ng, 05 Aug 2015
Concerns emerge over combining antidepressants with non-steroidal anti-inflammatory drugs (NSAIDs) as a study shows an increased risk of intracranial haemorrhage (ICH) in these patients. 
01 Oct 2015
BLACKMORES ESSENTIAL LIVO – Phosphatidylcholine, Zinc and Chromium Capsules
Debra Kennedy, 01 Jun 2014

Pregnant women do not need to suffer unnecessary pain or potentially dangerous fever for fear of their taking medications that may be harmful to their unborn baby. Healthcare providers should be confident when prescribing appropriate treatment to such women during pregnancy.

13 Dec 2016
Any abnormal decrease in a person’s usual bowel movement frequency and/or pain during stool passage is termed as Constipation.

Death, recurrence in NSCLC not tied to opioid usage

29 Jul 2017
More than 33,000 have died in America from opioid overdose in 2015 alone.

Opioid usage is not associated with long-term outcomes such as death and risk of recurrence in non-small cell lung cancer (NSCLC) patients, a new study has found.

The study included 871 NSCLC patients stratified into quartiles according to opioid use. Only patients who underwent sleeve lobectomy, bilobectomy or lobectomy were included. Exclusion criteria included death, need for revision surgery, occurrence of a different primary cancer within 5 years and incomplete medical records.

Multivariate logistic regression models showed that opioid dosage was not associated with either recurrence (Wald chi-square, 0.4128; p=0.520) or death (Wald chi square, 0.1939; p=0.659). However, when taking cancer stage into account, opioid use was significantly correlated with recurrence (p=0.004) and death (p=0.049).

A 1-unit increase in opioid dosage was correlated with a significant increase in recurrence for cancer stages IA (odds ratio [OR], 1.001; 95 percent CI, 1.001 to 1.001; p=0.004), IB (OR, 1.001; 1.000 to 1.001; p=0.02) and IB (OR, 1.001; 1.001 to 1.002; p=0.0006).

Similar significant increases in the risk of death in cancer stages IA (OR, 1.001; 1.000 to 1.001; p=0.0105), IB (OR, 1.001; 1.000 to 1.001; p=0.0317) and IIB (OR, 1.001; 1.000 to 1.001; p=0.0363) were calculated with a 1-unit increase in opioid dosage.

However, because of the small magnitude of the ORs, it may be concluded that opioid usage does not affect risk of death or recurrence in NSCLC regardless of stage, researchers said.

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Most Read Articles
Jenny Ng, 05 Aug 2015
Concerns emerge over combining antidepressants with non-steroidal anti-inflammatory drugs (NSAIDs) as a study shows an increased risk of intracranial haemorrhage (ICH) in these patients. 
01 Oct 2015
BLACKMORES ESSENTIAL LIVO – Phosphatidylcholine, Zinc and Chromium Capsules
Debra Kennedy, 01 Jun 2014

Pregnant women do not need to suffer unnecessary pain or potentially dangerous fever for fear of their taking medications that may be harmful to their unborn baby. Healthcare providers should be confident when prescribing appropriate treatment to such women during pregnancy.

13 Dec 2016
Any abnormal decrease in a person’s usual bowel movement frequency and/or pain during stool passage is termed as Constipation.