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Death, CV risks increase with reduced renal function in diabetics

17 Jul 2020

Poor renal function contributes to a significant burden of disease in patients with diabetes, such that estimated glomerular filtration rate (eGFR) levels <90 mL/min/1.73 m2 are associated with increased mortality and cardiovascular (CV) hospitalizations, a study reports.

The study included 19,469 adults with diabetes, of whom 83.2 percent had hypertension, 85.9 percent had dyslipidaemia, 49.6 percent were obese, and 21.7 percent were current smokers. The eGFR level was <60 mL/min/1.73 m2 in 2,868 (14.7 percent) individuals, with 810 (4.2 percent) having even lower eGFR levels (≤45 mL/min/1.73 m2).

Patients with lower eGFR were older, predominantly women, and more likely to be obese and have arterial hypertension and dyslipidaemia. They also had lower levels of good cholesterol and were less likely to smoke.

Over a mean follow-up of 3.2 years, 506 deaths, 925 hospitalizations for coronary heart disease (CHD), and 795 hospitalizations for stroke were recorded. Notably, the cumulative risk of the individual events increased as eGFR levels decreased.

The population attributable risk associated with having an eGFR of 60 mL/min/1.73 m2 was 11.4 percent (95 percent confidence interval [CI], 4.8–18.3) for all-cause mortality, 9.2 percent (95 percent CI, 5.3–13.4) for CHD, and 2.6 percent (95 percent CI, 1.8–7.4) for stroke.

The present data underscore the need to intensify primary cardiovascular disease prevention and control in patients with diabetes, the researchers said.

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Most Read Articles
4 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.