Most Read Articles
Stephen Padilla, Yesterday
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

Death, CV risks increase with reduced renal function in diabetics

17 Jul 2020

Poor renal function contributes to a significant burden of disease in patients with diabetes, such that estimated glomerular filtration rate (eGFR) levels <90 mL/min/1.73 m2 are associated with increased mortality and cardiovascular (CV) hospitalizations, a study reports.

The study included 19,469 adults with diabetes, of whom 83.2 percent had hypertension, 85.9 percent had dyslipidaemia, 49.6 percent were obese, and 21.7 percent were current smokers. The eGFR level was <60 mL/min/1.73 m2 in 2,868 (14.7 percent) individuals, with 810 (4.2 percent) having even lower eGFR levels (≤45 mL/min/1.73 m2).

Patients with lower eGFR were older, predominantly women, and more likely to be obese and have arterial hypertension and dyslipidaemia. They also had lower levels of good cholesterol and were less likely to smoke.

Over a mean follow-up of 3.2 years, 506 deaths, 925 hospitalizations for coronary heart disease (CHD), and 795 hospitalizations for stroke were recorded. Notably, the cumulative risk of the individual events increased as eGFR levels decreased.

The population attributable risk associated with having an eGFR of 60 mL/min/1.73 m2 was 11.4 percent (95 percent confidence interval [CI], 4.8–18.3) for all-cause mortality, 9.2 percent (95 percent CI, 5.3–13.4) for CHD, and 2.6 percent (95 percent CI, 1.8–7.4) for stroke.

The present data underscore the need to intensify primary cardiovascular disease prevention and control in patients with diabetes, the researchers said.

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Most Read Articles
Stephen Padilla, Yesterday
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
01 Aug 2020
Ensituximab, a chimeric monoclonal antibody targeting a variant of MUC5AC, shows modest clinical activity with good safety profile in patients with refractory colorectal cancer, according to data from a phase II study.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.