Most Read Articles
Pearl Toh, 01 Apr 2020
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When treating fibromyalgia patients with low-dose naltrexone, the 4.5-mg dose appears to be a good choice, according to a recent study.
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Dapagliflozin may confer renal protection

15 Sep 2019

Sodium-glucose transport protein 2 (SGLT2) inhibitors exert a putative epigenetic regulation of the protecting cardiovascular effect, reports a study, adding that dapagliflozin may protect the kidneys by preserving renal vasodilating capacity.

To determine whether dapagliflozin modulated systemic and renal vascular function and structure and induced epigenetic modification, 40 hypertensive patients with type 2 diabetes were randomized to 4-week treatment with dapagliflozin 10 mg or hydrochlorothiazide (HCT) 12.5 mg.

The investigators performed routine analyses and measured the following at baseline and after treatment: plasma renin activity, aldosterone, catecholamine and 24-hour urinary electrolyte levels; flow-mediated dilation (FMD) of the brachial artery; carotid-femoral pulse-wave velocity (PWV); augmentation index; and resistive index and dynamic renal resistive index (DRIN).

Circulating miRNAs (miRs) associated with heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b) and renal function (miR130b-3p, miR21-5p) were evaluated and compared with the treatment effects.

Dapagliflozin and HCT slightly reduced blood pressure. Dapagliflozin also lowered fasting glucose and increased 24-hour diuresis, glycosuria and osmolar clearance (p-all<0.001), without affecting sodium excretion and glomerular filtration rate. Treatment with dapagliflozin also led to a significant increase in magnesium levels (p=0.02).

Both dapagliflozin and HCT did not modify FMD or PWV. While DRIN did not change in the dapagliflozin group, it increased in the HCT group (p-interaction=0.047). The two treatments also resulted in variations in the expression of some miRs, but only dapagliflozin significantly upregulated miR30e-5p and downregulated miR199a-3p.

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Most Read Articles
Pearl Toh, 01 Apr 2020
Short-term treatment (6 weeks) with 10 mg prednisolone effectively reduces finger pain and improves function in patients who have painful hand osteoarthritis (OA) coupled with signs of inflammation, the HOPE* study has shown.
31 Mar 2020
When treating fibromyalgia patients with low-dose naltrexone, the 4.5-mg dose appears to be a good choice, according to a recent study.
Elaine Soliven, 21 Apr 2020
Adding liraglutide to first-line lifestyle therapy led to a significantly reduced BMI standard-deviation score (BMI SDS*) among obese adolescents who failed to respond to lifestyle therapy alone, according to a study presented at ENDO 2020.
Elvira Manzano, 04 Mar 2020
Some patients with colitis are more likely than others to develop cuffitis after proctocolectomy with ileal pouch-anal anastomosis (IPAA), according to a retrospective study presented at the annual Crohn’s & Colitis Congress.