Dairy product intake may increase incidence of hip arthroplasty for OA in men
Increasing consumption of dairy products may heighten the risk of total hip arthroplasty for men with osteoarthritis (OA), according to a study, adding that such an association is not seen in women.
In this prospective cohort study that sought to determine whether dairy product consumption was associated with the incidence of total hip arthroplasty for OA, researchers enrolled 38,924 participants who had dairy product intake recorded from 1990 to 1994.
The authors determined the incidence of total hip arthroplasty for OA during 2001 to 2013 by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry.
There were 1,505 total hip arthroplasties for OA (524 in men and 981 in women) over an average follow-up of 11.8 years. A 1 SD increase in dairy product consumption was associated with a 21-percent rise in incidence of total hip arthroplasty for OA in men (hazard ratio [HR], 1.21; 95 percent CI, 1.10 to 1.33), with a dose-response relationship seen for quartiles of dairy product intake (p=0.001 for trend).
This association was independent of age, body mass index, country of birth, education, smoking status, vigorous physical activity, energy consumption, calcium supplementation, diabetes, hypertension and circulating 25-hydroxy vitamin D.
There was no significant association observed for women (HR, 1.02; 0.95 to 1.09), according to researchers, adding that understanding the mechanisms may help develop strategies to prevent hip OA, particularly for men.
In an earlier study, researchers found an association between increasing concentrations of serum 25-hydroxy vitamin D and an elevated risk of hip arthroplasty for OA in men, whereas no significant association was found in women. [Osteoarthritis Cartilage 2015;23:2134-40]