Most Read Articles
Audrey Abella, 20 Nov 2020
Metformin may improve vascular function in chronic kidney disease (CKD) patients with metabolic syndrome (MetS), according to a study presented at ASN Kidney Week 2020.

Daily supplementation with 2,000 IU vitamin D reduces SBP in adults

06 Sep 2020

Daily vitamin D supplementation with either 2,000 or 800 IU dose results in lower mean systolic blood pressure (SBP) over 2 years to a “small and similar extent,” but 2,000 IU reduces mean SBP variability more significantly than 800 IU, results of a recent study have shown.

“However, without a placebo control group we cannot ascertain whether vitamin D supplementation effectively reduces BP,” the authors said.

To determine if daily vitamin D supplementation with 2,000 IU is more effective than 800 IU for BP control among older adults, a randomized double-blind, ancillary trial was conducted. A total of 273 adults aged ≥60 years who underwent elective surgery due to severe knee osteoarthritis were enrolled and randomly assigned to receive high-dose (2,000 IU) or standard dose (800 IU) daily vitamin D3 for 24 months. Outcomes analysed were daytime and 24-h mean SBP.

Moreover, the authors examined BP variability and serum 25-hydroxyvitamin D concentration in a posthoc and observational analysis.

Two hundred fifty participants (mean age, 70.4±6.4 years; 47.2 percent men) completed a follow-up 24-h ambulatory BP monitoring. No statistically significant difference was found in daytime mean SBP reduction between the 2,000 IU (n=123) and 800 (n=127) groups (–2.75 vs –3.94 mm Hg; difference, 1.18 mm Hg, 95 percent confidence interval [CI], –0.68 to 3.05; p=0.21), consistent with 24-h mean SBP.

However, the 2,000 IU dose led to a significant reduction in SBP variability compared with the 800 IU vitamin D3 (average real variability, –0.37 vs 0.11 mm Hg; difference, –0.48 mm Hg, 95 percent CI, –0.94 to –0.01; p=0.045).

“Independent of group allocation, maximal reductions in mean BP were observed at 28.7 ng/mL of achieved serum 25-hydroxyvitamin D concentrations,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Audrey Abella, 20 Nov 2020
Metformin may improve vascular function in chronic kidney disease (CKD) patients with metabolic syndrome (MetS), according to a study presented at ASN Kidney Week 2020.