Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

Daily supplementation with 2,000 IU vitamin D reduces SBP in adults

06 Sep 2020

Daily vitamin D supplementation with either 2,000 or 800 IU dose results in lower mean systolic blood pressure (SBP) over 2 years to a “small and similar extent,” but 2,000 IU reduces mean SBP variability more significantly than 800 IU, results of a recent study have shown.

“However, without a placebo control group we cannot ascertain whether vitamin D supplementation effectively reduces BP,” the authors said.

To determine if daily vitamin D supplementation with 2,000 IU is more effective than 800 IU for BP control among older adults, a randomized double-blind, ancillary trial was conducted. A total of 273 adults aged ≥60 years who underwent elective surgery due to severe knee osteoarthritis were enrolled and randomly assigned to receive high-dose (2,000 IU) or standard dose (800 IU) daily vitamin D3 for 24 months. Outcomes analysed were daytime and 24-h mean SBP.

Moreover, the authors examined BP variability and serum 25-hydroxyvitamin D concentration in a posthoc and observational analysis.

Two hundred fifty participants (mean age, 70.4±6.4 years; 47.2 percent men) completed a follow-up 24-h ambulatory BP monitoring. No statistically significant difference was found in daytime mean SBP reduction between the 2,000 IU (n=123) and 800 (n=127) groups (–2.75 vs –3.94 mm Hg; difference, 1.18 mm Hg, 95 percent confidence interval [CI], –0.68 to 3.05; p=0.21), consistent with 24-h mean SBP.

However, the 2,000 IU dose led to a significant reduction in SBP variability compared with the 800 IU vitamin D3 (average real variability, –0.37 vs 0.11 mm Hg; difference, –0.48 mm Hg, 95 percent CI, –0.94 to –0.01; p=0.045).

“Independent of group allocation, maximal reductions in mean BP were observed at 28.7 ng/mL of achieved serum 25-hydroxyvitamin D concentrations,” the researchers said.

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.