Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Daily aspirin use may prevent fibrosis progression in nonalcoholic fatty liver disease

08 Jun 2019

Use of aspirin on a daily basis appears to be associated with less severe histologic features of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), as well as reduce the risk of progression to advanced fibrosis with time, a study has found.

Researchers examined 361 adults with biopsy-confirmed NAFLD every 3–12 months for incident advanced fibrosis defined using serial measurements of validated indices (the Fibrosis-4, NAFLD fibrosis score and aspartate aminotransferase to platelet ratio indices). Liver biopsies were collected at baseline for histologic analyses.

At baseline, 151 patients reported daily aspirin use. Compared with nonregular users, daily users had a significantly lower likelihood of NASH (adjusted odds ratio [aOR], 0.68, 95 percent CI, 0.37–0.89) and fibrosis (aOR, 0.54, 0.31–0.82).

In the group of patients with baseline F0-F2 fibrosis (n=317), 86 developed advanced fibrosis over 3,692 person-years. Daily aspirin use was associated with a significantly lower risk of developing incident advanced fibrosis compared with nonregular users (adjusted hazard ratio [aHR], 0.63, 0.43–0.85).

The relationship between fibrosis progression and aspirin use was dependent of duration of use (p-trend=0.026), with the greatest benefit found in daily aspirin users for 4 years (aHR, 0.50, 0.35–0.73).

In contrast, use of nonaspirin nonsteroidal anti-inflammatory drugs was not associated with the risk of advanced fibrosis (aHR, 0.93, 0.81–1.05).

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.