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Daily alcohol consumption amplifies diabetes risk

20 May 2020
Variety of craft beers

In Japanese patients, drinking alcohol daily may impair insulin secretion and increase the risk of diabetes, a recent study has found.

Researchers conducted a retrospective study of 452 men and 659 women (both groups aged 40–78 years) who were made to complete a 75-g oral glucose tolerance test and accomplish a medical questionnaire.  Insulin sensitivity was measured according to the homeostasis model assessment of β-cell function (HOMA-β) and insulinogenic index.

Participants were grouped into four according to alcohol consumption patterns: nondrinkers (n=387) and alcohol drinkers who consumed 0–19.9 g/day (n=453), 20–39.9 g/day (n=109) and 40.0 g/day (n=129).

The highest alcohol intake category was significantly more likely to have decreased HOMA-β values than the nondrinkers (odds ratio [OR], 2.68, 95 percent confidence interval [CI], 1.27–5.74). This was especially true among men (OR, 3.11, 95 percent CI, 1.30–7.78).

Similarly, levels of γ-glutamyltranspeptidase were also significantly elevated in the highest category of alcohol intake (OR, 3.24, 95 percent CI, 1.38–7.95), especially in men (OR, 4.56, 95 percent CI, 1.73–13.42).

Glycated haemoglobin levels after 5 years were also nominally more likely to be higher in the 0–19.9 (OR, 1.65, 95 percent CI, 0.53–5.61), 20–39.9 (OR, 3.42, 95 percent CI, 0.62–16.29) and ≥40.0 (OR, 4.01, 95 percent CI, 0.51–15.63) grams of alcohol per day consumption groups, respectively, relative to nondrinking controls.

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).