Most Read Articles
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia. 
15 Nov 2017
New drug applications approved by US FDA as of 1 - 15 November 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Jairia Dela Cruz, 16 Nov 2017
Treatment with a ribavirin-free regimen of coformulated glecaprevir plus pibrentasvir appears to yield a high rate of sustained virologic response in hepatitis C virus-infected patients with advanced chronic kidney disease, while having an acceptable safety profile, according to the EXPEDITION-4 trial.
Roshini Claire Anthony, 17 Nov 2017

Use of the blood infection biomarker procalcitonin as a guide to prescribing antibiotics led to lower antibiotic exposure and side effects, as well as a lower mortality rate in individuals with acute respiratory infections, based on findings of a meta-analysis.

Daclatasvir plus asunaprevir effective, tolerable in older and younger genotype 1 HCV patients

04 Apr 2017

Virological response and tolerance with daclatasvir plus asunaprevir therapy appear to be similar between older and younger patients with chronic genotype 1 hepatitis C virus (HCV) infection, a study has shown.

A total of 170 genotype 1 HCV-infected patients in the younger cohort (<75 years) and 139 in the older cohort (≥75 years) received dual therapy with daclatasvir plus asunaprevir for 24 weeks. Efficacy and safety outcomes—virological response and adverse events, respectively—were analysed according to age. The Invader assay facilitated identification of pretreatment resistance-associated variants (RAVs) at NS5A-L31 and NS5A-Y93.

At treatment completion, the sustained virological response (SVR) rate did not differ significantly between the older and younger cohorts (97.1 vs 92.4 percent, respectively). Of note was that all very elderly patients in the cohort (≥85 years; n=19) completed the 24 weeks of treatment and achieved SVR.

On multivariate regression analysis, the absence of prior simeprevir treatment significantly and independently predicted SVR (odds ratio, 56.6; p<0.001).

At a low population frequency (<25 percent), the SVR rate was similar between patients with RAVs and those with no detectable RAVs. The frequency of adverse events was also similar between younger and older patients.

The present data provide evidence of the safety and efficacy of the daclatasvir and asunaprevir dual therapy for older patients with chronic genotype 1 HCV infection, with virological response and tolerance comparable to that of younger patients.

“Even though RAVs were detected, virological response similar to that for patients with no detectable RAVs may still be expected for patients with RAVs as long as the population frequency is low,” researchers said.

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Most Read Articles
02 Nov 2017
In this issue of MIMS Anti-Infective Supplement, we bring you clinical updates related to combating infectious diseases, and also a symposium highlight in conjunction with the launch of ceftolozane/tazobactam (Zerbaxa; Merck Sharp & Dohme Sdn Bhd) in Malaysia. 
15 Nov 2017
New drug applications approved by US FDA as of 1 - 15 November 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
Jairia Dela Cruz, 16 Nov 2017
Treatment with a ribavirin-free regimen of coformulated glecaprevir plus pibrentasvir appears to yield a high rate of sustained virologic response in hepatitis C virus-infected patients with advanced chronic kidney disease, while having an acceptable safety profile, according to the EXPEDITION-4 trial.
Roshini Claire Anthony, 17 Nov 2017

Use of the blood infection biomarker procalcitonin as a guide to prescribing antibiotics led to lower antibiotic exposure and side effects, as well as a lower mortality rate in individuals with acute respiratory infections, based on findings of a meta-analysis.