Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Tristan Manalac, 6 days ago
Elderly coronavirus disease 2019 (COVID-19) patients with high nutritional risk appear to suffer worse outcomes, such as longer hospital stay and greater disease severity, according to a recent study.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.

Dabigatran use cuts risk of S. aureus bacteraemia in AF patients

16 Jun 2020

Among patients with atrial fibrillation (AF), treatment with the direct thrombin inhibitor dabigatran results in a significantly lower incidence of Staphylococcus aureus bacteraemia (SAB) as compared with factor Xa-inhibitors, a study has shown.

The analysis involved 112,537 AF patients (median age, 73 years; 54.8 percent male) who initiated treatment with direct oral anticoagulants. Compared with factor-Xa-inhibitor users, those who used dabigatran were younger, more often men, and had a lower prevalence of comorbidities.

Over a median follow-up of 2 years, 186 dabigatran users and 356 factor Xa-inhibitor users were hospitalized for SAB. The crude incidence rates of bacteraemia were 22.8 and 33.8 events per 10.000 person-years, respectively.

Multivariable Cox regression accounting for time-dynamic changes of exposure status during follow-up revealed dabigatran to be associated with a significantly lower incidence rate of SAB compared with factor Xa-inhibitors (incidence rate ratio, 0.76, 95 percent confidence interval,0.63–0.93).

The present data indicate that inhibition of the staphylothrombin complex via dabigatran helps reduce the risk of developing SAB and thus support those from preclinical studies, the researchers said. More studies are needed to establish the antibacterial activity of dabigatran against S. aureus infections in humans.

The researchers also stressed that since the study was observational and exploratory in nature, the findings should not be interpreted as dabigatran having an advantage over factor Xa-inhibitors and hence not encourage a change in the choice of anticoagulant therapy in AF.

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Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Tristan Manalac, 6 days ago
Elderly coronavirus disease 2019 (COVID-19) patients with high nutritional risk appear to suffer worse outcomes, such as longer hospital stay and greater disease severity, according to a recent study.
01 Jan 2019
Twice-daily administration of a combined Lactobacillus rhamnosus and Lactobacillus helveticus probiotic in children with suspected gastroenteritis fails to prevent the development of moderate-to-severe gastroenteritis within 2 weeks after presentation, as shown in a recent study.
25 Oct 2018
Human papillomaviruses (HPVs) are commonly found in the oral cavity, but it does not appear that oral HPVs contribute to an increased risk of oesophageal cancer, according to a study.