Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Cysts in kidney may signal stroke risk

Pearl Toh
02 Feb 2018

Presence of fluid sacs in the kidneys may be indicative of an increased risk of stroke, suggest preliminary data from a study presented at the International Stroke Conference (ISC) 2018 in Los Angeles, California, US.

“This data questions the general consensus that renal cysts are of no clinical significance as they might signal higher degrees of vascular damages in the brain circulation,” said lead author Dr Sanaz Sedaghat from Erasmus University Medical Center in Rotterdam, the Netherlands, who added that renal cysts are common in older people and have generally been regarded as benign.  

The population-based study involved 2,984 participants (mean age 71.9 years, 57 percent females) in the Rotterdam Study who underwent a renal ultrasound between 2009–2014. Stroke and transient ischaemic attacks (TIAs) were identified from digital medical records. Seventeen percent of the participants presented with a single cyst and 6.6 percent showed multiple cysts. [ISC 2018, abstract P145 Session A25]

Sedaghat and team found that the more cysts a participant carried, the higher the risk of having stroke. Compared with participants without cyst, participants with a single renal cyst had a 63 percent increased risk of stroke (odds ratio [OR], 1.63, 95 percent confidence interval [CI], 1.01–2.64), while those with multiple renal cysts were more than twice as likely to experience a stroke (OR, 2.14, 95 percent CI, 1.20–3.82).

The associations were independent of known risk factors for stroke such as age, history of cardiovascular disease, high blood pressure, diabetes, and smoking status.

No significant association was found between renal cysts, regardless of single or multiple, and the risk of TIAs (OR, 1.06, 95 percent CI, 0.70–1.59 and 1.29, 95 percent CI, 0.74–2.23, respectively). 

According to the researchers, renal cysts usually cause no symptoms and are often discovered during an ultrasound or CT scan that is done for another purpose. Although conventionally considered as benign kidney structural changes, the researchers said recent studies have suggested that renal cysts might be indicative of early-stage kidney damage. 

“In this large population-based study, we show that there is a dose-dependent association between renal cysts and prevalent stroke,” said Sedaghat.

 

 

Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.