Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Cysteamine eye drops deliver limited efficacy in nephropathic cystinosis

10 Sep 2017

The use of topical 0.55% cysteamine eye drops appears to have limited effects in reducing the corneal cystine deposits in patients with severe forms of nephropathic cystinosis, according to a recent study.

A total of 32 patients (mean age 8 years; range, 8 months to 19 years; 19 female) with nephropathic cystinosis were prospectively included in the study, with a mean follow-up period of 4.1 years (range, 2 to 8 years).

There was no clinically significant improvement of photophobia among symptomatic patients. During the follow-up period, participants demonstrated statistically significant worsening of corneal cystine deposits.

In this study that investigated the efficacy of topical cysteamine 0.55% eye drops in the treatment of corneal cystine crystal deposits in patients with nephropathic cystinosis, patients were administered the said medication. They were examined prior to treatment, on each monthly visit and after treatment at the last follow-up.

The main outcome was evaluation of photophobia and resolution of corneal cystine crystals.

Photophobia was classified as grade 0 (none) for no photophobia, grade 1 (mild) for photophobia in bright light, grade 2 (moderate) for photophobia in room light and grade 3 (severe) for photophobia in dim light. Corneal cystine crystals were classified as grade 0 for none, grade 1 for 1 to 10 crystals/mm2, grade 2 for 11 to 50 crystals/mm2, grade 3 for more than 50 crystals/mm2.

Nephropathic cystinosis is a rare genetic disease characterized by defective lysosomal cystine transport and increased lysosomal cystine. [Saudi J Kidney Dis Transpl 2009;20:436-42]

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.