Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 2 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Cyclosporine shows promise in treatment of moderate-to-severe alopecia areata

25 Aug 2019

Treatment with cyclosporine results in improvements, albeit statistically nonsignificant, in the Severity of Alopecia Tool score and eyelash and eyebrow assessment scales among patients with moderate-to-severe alopecia areata (AA), a recent study has shown.

Thirty-two patients were included in the analysis, of whom 16 received cyclosporine and 16 placebo. A greater proportion of participants in the cyclosporine group achieved at least a 50-percent reduction in the Severity of Alopecia Tool score (31.3 percent vs 6.3 percent; p=0.07) and a 1-grade improvement in eyelash (18.8 percent vs 0 percent; p=0.07) and eyebrow (31.3 percent vs 0 percent; p=0.02) scale score compared with those in the placebo group.

“Small sample size and single-institution trial may limit interpretation and generalizability of these results,” the investigators said.

In another study, treatment with oral cyclosporin for moderate-to-severe AA for 3 months resulted in trends for improvement in quality of life across multiple dimensions in both disease-specific and generic measures. [J Dermatolog Treat 2019;doi:10.1080/09546634.2019.1654068]

This double-blind, randomized, placebo-controlled trial was performed to assess the efficacy of cyclosporine compared with placebo in patients aged 18–65 years with moderate-to-severe AA. Participants were randomized 1:1 to receive 3 months of cyclosporine (4 mg/kg/d) or matching placebo.

Blinded assessments included the following: physical examination, blood biochemistry, photography, quality of life measurements, and efficacy evaluation using the Severity of Alopecia Tool score and eyelash and eyebrow assessment scales.

AA is a common autoimmune disease that often results in unpredictable hair loss with substantial psychological burden.

Editor's Recommendations
Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 3 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 2 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.