Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

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Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Cyclophosphamide, rituximab tied to less permanent organ damage in older polyangiitis patients

16 Apr 2020

Immunosuppressive treatment with cyclophosphamide and rituximab in elderly patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) is not associated with hospitalization and may result in the development of less permanent organ damage, reveals a study.

However, higher doses of corticosteroids during the first 3 months lead to treatment-related damage and fatal infections.

Of the 202 patients identified, 167 had available treatment data. Four percent of these patients had no items of damage at 2 years.

A positive association was seen between Vasculitis Damage Index (VDI) score at 2 years and Birmingham Vasculitis Activity Score at onset, while a negative association was found with cyclophosphamide or rituximab therapy. On the other hand, intravenous methylprednisolone dose correlated with treatment-related damage.

Sixty-nine percent of patients were readmitted to the hospital during the first year. The risk of readmission decreased with myeloperoxidase–antineutrophil cytoplasmic antibody positivity and lower creatinine levels. Infection was the most common cause of death and correlated with cumulative oral prednisolone dose.

The study identified consecutive patients from Sweden, UK and the Czech Republic diagnosed between 1997 and 2013 and included those with a diagnosis of MPA or GPA and aged 75 years at diagnosis. Treatment with cyclophosphamide, rituximab and corticosteroids for the first 3 months was recorded. Outcomes up to 2 years from diagnosis were VDI, hospitalization and cause of death.

“Age is a risk factor for organ damage, adverse events and mortality in MPA and GPA,” the authors said.

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Most Read Articles
5 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
4 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Yesterday
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.