CVD risk higher in systemic lupus, psoriasis and rheumatoid arthritis
The prevalence of cardiovascular diseases (CVDs) is higher in rheumatoid arthritis, psoriasis and systemic lupus erythematosus than in other immune-mediated inflammatory diseases (IMIDs), a new cross-sectional analysis has shown.
The analysis of six cohorts (n=9,951) showed that, using the rheumatoid arthritis cohort as a reference, CVD risk was moderately lower in the psoriasis (odds ratio [OR], 0.89; 95 percent CI, 0.66 to 1.19; p=0.42) and systemic lupus erythematosus (OR, 0.74; 0.47 to 1.17; p=0.19) cohorts before adjustments.
In contrast, the risk of CVD was significantly lower in the ulcerative colitis (OR, 0.35; 0.22 to 0.56; p<0.001), Crohn’s disease (OR, 0.16; 0.09 to 0.29; p<0.001) and psoriatic arthritis (OR, 0.48; 0.31 to 0.76; p=0.002) cohorts compared to the rheumatoid arthritis cohort before adjustments.
After adjusting for demographic variables, educational level and traditional CV risk factors, multivariable models showed that the psoriasis (OR, 0.67; 0.42 to 1.05; p=0.078) and Crohn’s disease (OR, 0.50; 0.23 to 1.09; p=0.083) cohorts had nonsignificantly lower risks of CVD compared with the rheumatoid arthritis cohort.
The risk of CVD was significantly lower in the psoriatic arthritis (OR, 0.46; 0.23 to 0.92; p=0.028) and ulcerative colitis (OR, 0.35; 0.16 to 0.75; p=0.007) cohorts. In contrast, the risk of CVD was significantly higher in the systemic lupus erythematosus vs the rheumatoid arthritis cohort (OR, 3.64; 1.93 to 6.85; p<0.001) in multivariate analysis.
Any diagnosis of myocardial infarction, stroke, peripheral vascular disease or angina after identification of IMIDs was defined as the presence of CVD and was designated as the dependent outcome.
Of the 9,951 participants, 2,152 had rheumatoid arthritis, 1,147 had psoriatic arthritis, 2,497 had psoriasis, 760 had systemic lupus erythematosus, 1,938 had Crohn’s disease and 1,457 had ulcerative colitis.