Most Read Articles
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Current smoking ups death, hospitalization in HFpEF patients

12 Sep 2018

Current smoking increases the likelihood of adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF), a recent study has shown.

Researchers analysed 1,717 patients with HFpEF (mean age 71±10 years; 50 percent male), most of whom (51 percent; n=871) were former smokers. Seven percent (n=116) and 42 percent (n=729) were current and never smokers, respectively.

Over a median follow-up period of 2.9 years, researchers observed 387 hospitalizations for heart failure. Cox regression analysis showed that compared with former smokers, current smokers were significantly more likely to be hospitalized for heart failure (hazard ratio [HR], 1.68; 95 percent CI, 1.08–2.61; p=0.02).

In the same time span, there were 374 deaths recorded, majority of which (n=218) were cardiovascular in nature. Relative to never smoking, current smoking was likewise associated with significantly higher risks of death (HR, 1.82; 1.19–2.78; p=0.0057) and cardiovascular death (HR, 1.85; 1.09–3.14; p=0.022).

No such effect was observed for former smoking compared with never smoking (hospitalization for heart failure: HR, 1.25; 0.99–1.57; p=0.053; death: HR, 1.02; 0.81–1.29; p=0.85; cardiovascular death: HR, 1.00; 0.74–1.35; p=0.99).

Analyses were adjusted for age, sex, race, body mass index, aspirin and antihypertensive medication use, systolic blood pressure, and comorbidities such as diabetes, chronic obstructive pulmonary disease, stroke and coronary heart disease.

Though further studies are needed to confirm these findings, the present results suggest that smoking cessation programmes may be beneficial to HFpEF patients, said researchers.

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Most Read Articles
17 Jul 2018
Higher total intake of dairy products, especially yogurt, may help reduce the risk of incident hypertension in middle-aged and older adult men and women, suggests a recent study.
12 May 2019
Regular consumption of chili pepper is associated with reduced risk of total and cardiovascular death regardless of adherence to Mediterranean diet, according to a study from Italy.
19 Oct 2016
A new system called Preoperative Evaluation Clinic (PEC) workflow for cardiothoracic surgery significantly reduced the cancellation rate of elective cases at the National Heart Centre Singapore (NHCS), according to a study presented at the ASEAN Federation of Cardiology Congress (AFCC) 2016 in Yangon, Myanmar.
Pearl Toh, 19 Dec 2018
A structured cardiovascular (CV) exercise programme during adjuvant breast cancer treatment provides significant protection against decline in CV function related to chemotherapy-induced cardiotoxicity, according to the EBBA*-II trial presented at SABCS 2018, indicating that physical activity during treatment for breast cancer can benefit patients.