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Current smoking ups death, hospitalization in HFpEF patients

12 Sep 2018

Current smoking increases the likelihood of adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF), a recent study has shown.

Researchers analysed 1,717 patients with HFpEF (mean age 71±10 years; 50 percent male), most of whom (51 percent; n=871) were former smokers. Seven percent (n=116) and 42 percent (n=729) were current and never smokers, respectively.

Over a median follow-up period of 2.9 years, researchers observed 387 hospitalizations for heart failure. Cox regression analysis showed that compared with former smokers, current smokers were significantly more likely to be hospitalized for heart failure (hazard ratio [HR], 1.68; 95 percent CI, 1.08–2.61; p=0.02).

In the same time span, there were 374 deaths recorded, majority of which (n=218) were cardiovascular in nature. Relative to never smoking, current smoking was likewise associated with significantly higher risks of death (HR, 1.82; 1.19–2.78; p=0.0057) and cardiovascular death (HR, 1.85; 1.09–3.14; p=0.022).

No such effect was observed for former smoking compared with never smoking (hospitalization for heart failure: HR, 1.25; 0.99–1.57; p=0.053; death: HR, 1.02; 0.81–1.29; p=0.85; cardiovascular death: HR, 1.00; 0.74–1.35; p=0.99).

Analyses were adjusted for age, sex, race, body mass index, aspirin and antihypertensive medication use, systolic blood pressure, and comorbidities such as diabetes, chronic obstructive pulmonary disease, stroke and coronary heart disease.

Though further studies are needed to confirm these findings, the present results suggest that smoking cessation programmes may be beneficial to HFpEF patients, said researchers.

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Most Read Articles
05 Apr 2019
The risk of venous thromboembolism in men appears to be elevated in the presence of erectile dysfunction, a study has reported.
23 Sep 2018
Supplementation with n−3 or omega-3 fatty acids does not help prevent serious vascular events in diabetic patients without evidence of cardiovascular disease at baseline, according to a study.
Tristan Manalac, 04 Aug 2018
Omega-3 fatty acid (FA) supplements do not yield significant cardiovascular benefits, according to a recent meta-analysis, which shows no reduction in fatal or nonfatal coronary heart disease (CHD) or major vascular events following supplementation.
20 Oct 2018
Seated diastolic blood pressure (DBP) show statistically significant inverse cross-sectional associations with total testosterone and sex hormone-binding globulin (SHBG), and a significant positive association with dehydroepiandrosterone sulphate (DHEAS), suggests a recent study.