Most Read Articles
3 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Elvira Manzano, 2 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
3 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
07 Nov 2019
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.

Cryptococcosis, 90-day mortality higher in non-HIV nontransplant patients

21 Sep 2019

Cryptococcosis is more common in nonhuman immunodeficiency virus (HIV) nontransplant (NHNT) patients, and this population tends to have more localized pulmonary cryptococcosis and significantly higher 90-day mortality, reports a study.

This single-centre, retrospective study included patients diagnosed with cryptococcosis from 2002 through 2007 and analysed data on demographics, clinical features, diagnostics and mortality.

Of the 304 patients with Cryptococcus neoformans infections, 105 (35 percent) were people living with HIV, 41 (13 percent) had a history of transplantation, and 158 (52 percent) were NHNT. In age analysis, people living with HIV were younger (40 years) than transplant (53 years) and NHNT (61 years; p<0.001).

Fevers and headache occurred more frequently in people living with HIV (70 percent and 57 percent) than in transplant (49 percent and 29 percent) and NHNT (49 percent and 38 percent; p=0.003 and p=0.001), respectively.

Meningitis was more common in people living with HIV (68 percent) as compared with transplant (32 percent) or NHNT (39 percent; p<0.001). Disseminated cryptococcosis also occurred frequently in people living with HIV (97 percent) than in transplant (66 percent) or NHNT (73 percent; p<0.001).

Transplant recipients (median, 2 days; interquartile range [IQR], ±9 days) and NHNT patients (median, 2 days; IQR, ±7 days) had longer time to diagnosis from hospitalization than people living with HIV (median, 1 day; IQR ±2 days; p=0.003).

Moreover, the risk of 90-day mortality was higher in NHNT patients (hazard ratio, 3.3, 95 percent CI, 1.9–5.8) than in people living with HIV.

“Cryptococcosis in NHNT patients appears to be a distinct entity that needs further study and requires a higher level of clinical suspicion than it currently receives,” the authors said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Infectious Diseases - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Elvira Manzano, 2 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
3 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
07 Nov 2019
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.