Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 12 Oct 2020
Taking regular hot baths may have a positive impact on glycaemia, blood pressure (BP), and body weight among Japanese patients with type 2 diabetes(T2D), according to a real-world study touted as the first to analyse the effect of heat therapy in T2D.

CRP predicts insulin need in T2DM after lumbar spinal canal stenosis surgery

03 Feb 2020
Patients with type 3c diabetes are more likely to require insulin to help control their blood sugar levels.

Levels of C-reactive protein (CRP) appear to correlate with the insulin requirements of type 2 diabetes mellitus (T2DM) patients admitted for lumbar spinal canal stenosis surgery in the acute postoperative phase, a new study has found.

Researchers conducted a retrospective analysis of 49 patients corresponding to 286 records, collected during days when postoperative CRP levels were measured. The outcome of interest was the difference in the amount of daily insulin administered relative to the preoperative phase, with CRP, glucose intake and oral hypoglycaemic agent use as explanatory variables.

Linear mixed-effects models revealed a significant interaction between insulin needs and CRP levels. On average, patients required an additional 0.60 (95 percent confidence interval [CI], 0.33–0.86) U of insulin per day when their CRP levels increased to 1 mg/dL. A 1-percent difference in HbA1c further increased this effect size to 0.91 (95 percent CI, 0.52–1.30).

The other explanatory variables showed no individual significance in relation to insulin needs but improved the overall model performance upon inclusion.

In the present study, the final model was obtained by splitting the cohort into two: a training cohort, including 190 records from 32 patients, and a final test dataset, with 96 records from 17 patients. The final model achieved a Pearson’s correlation coefficient of 0.429 on cross-validation.

“The findings led us to speculate that CRP levels could be a metric for determining insulin requirements. Further prospective multicentre studies are needed to validate our findings,” said researchers.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Pearl Toh, 15 Oct 2020
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 12 Oct 2020
Taking regular hot baths may have a positive impact on glycaemia, blood pressure (BP), and body weight among Japanese patients with type 2 diabetes(T2D), according to a real-world study touted as the first to analyse the effect of heat therapy in T2D.