Most Read Articles
26 Nov 2019
Hypertension is associated with a high cardiovascular disease burden but does not appear to have any impact on symptoms or functional capacity during exercise treadmill test (ETT) in patients with aortic stenosis, results of a study have shown.
28 Nov 2019
Slideshow: Highlights from the American Heart Association (AHA) Scientific Sessions 2019
Elaine Soliven, 27 Nov 2019
High levels of trunk fat mass (FM) may be associated with an increased risk of cardiovascular disease (CVD)-related events such as coronary death, nonfatal myocardial infarction, or coronary heart disease in postmenopausal women with normal body mass index (BMI), according to a recent study presented at AHA 2019.
28 Oct 2019
The C-reactive protein (CRP)-to-albumin ratio (CAR) appears to be linked to the development of acute kidney injury in patients with ST elevation myocardial infarction (STEMI), a recent study has found.

Crohn’s disease poses increased myocardial infarction hazard

14 Oct 2019

Patients with Crohn’s disease (CD) appear to be at higher risk of developing myocardial infarction (MI), particularly female and younger patients, a study reports.

The study population included 37,477 individuals newly diagnosed with IBD (mean age, 40.4 years; 56.8 percent male; CD: n=10,708; ulcerative colitis [UC]: n=26,769) and 112,431 matched general population controls. Compared with controls, IBD patients had a higher prevalence of hypertension and dyslipidaemia (12.2 percent vs 11.5 percent and 5.6 percent vs 4.9 percent, respectively; p<0.001).

MI occurred in 146 CD patients vs 244 matched controls (incidence rate [IR], 1.64 vs 0.90 per 1,000 person-years) and in 440 UC patients vs 1,193 matched controls (IR, 1.98 vs 1.78 per 1,000 person‐years).

Multivariable Cox analysis revealed that the risk of MI was significantly higher in CD patients than in controls (hazard ratio [HR], 1.80, 95 percent CI, 1.47–2.21), and this trend was more prominent among patients aged <40 years (IR, 0.69 per 1,000 person-years; HR, 2.96, 1.96–4.47) and among female patients (IR, 2.35 per 1,000 person-years; HR, 2.18, 1.61–2.94).

On the other hand, in the UC group, only women had an elevated MI risk (IR, 2.01 per 1,000 person-years; HR, 1.33, 1.13–1.56).

Researchers explained that the larger effect noted in female IBD patients might be related to the more pronounced role of inflammation in coronary heart disease in women than in men. Specifically, women have a higher level of C‐reactive protein. Likewise, the greater magnitude of increase in cardiovascular risk in younger individuals might be attributed to inflammation levels. [J Am Coll Cardiol 2009;54:1561‐1575; Nat Rev Gastroenterol Hepatol 2015;12:26]

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Most Read Articles
26 Nov 2019
Hypertension is associated with a high cardiovascular disease burden but does not appear to have any impact on symptoms or functional capacity during exercise treadmill test (ETT) in patients with aortic stenosis, results of a study have shown.
28 Nov 2019
Slideshow: Highlights from the American Heart Association (AHA) Scientific Sessions 2019
Elaine Soliven, 27 Nov 2019
High levels of trunk fat mass (FM) may be associated with an increased risk of cardiovascular disease (CVD)-related events such as coronary death, nonfatal myocardial infarction, or coronary heart disease in postmenopausal women with normal body mass index (BMI), according to a recent study presented at AHA 2019.
28 Oct 2019
The C-reactive protein (CRP)-to-albumin ratio (CAR) appears to be linked to the development of acute kidney injury in patients with ST elevation myocardial infarction (STEMI), a recent study has found.