Creatinine kinase tied to severe gestational hypertension
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
A total of 3,619 pregnant women were included in this study, in whom plasma creatinine kinase activity significantly correlated with all blood pressure outcomes. This association was most noticeable for the mean systolic blood pressure throughout pregnancy (regression coefficient per 1-unit logCK, 3.48 mm Hg, 95 percent CI, 1.67–5.28; p<0.001).
For the hypertensive disorders in pregnancy, creatinine kinase was significantly associated only with severe gestational hypertension diagnosed before 34 weeks of gestation (odds ratio, 9.16, 1.32–63.86; p=0.025) per 1-unit logCK activity. No association was found with pre-eclampsia and HELLP syndrome.
To determine whether plasma creatine kinase activity is similarly associated with blood pressure during pregnancy, the investigators analysed women who participated in the Amsterdam Born Children and their Development Study.
Multiple linear regression and logistic regression models were used to evaluate the association of plasma creatinine activity with blood pressure measurements during pregnancy and with hypertensive disorders in pregnancy (ie, gestational hypertension, HELLP syndrome, pre-eclampsia and eclampsia).
“Hypertensive disorders in pregnancy pose a major burden during pregnancy and are also associated with an increased risk for hypertension later in life,” the investigators said. “Plasma creatine kinase activity is identified in the general population as an independent risk factor for hypertension.”