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Roshini Claire Anthony, 10 Jan 2020

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Creatinine kinase tied to severe gestational hypertension

07 Jul 2019

Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.

A total of 3,619 pregnant women were included in this study, in whom plasma creatinine kinase activity significantly correlated with all blood pressure outcomes. This association was most noticeable for the mean systolic blood pressure throughout pregnancy (regression coefficient per 1-unit logCK, 3.48 mm Hg, 95 percent CI, 1.67–5.28; p<0.001).

For the hypertensive disorders in pregnancy, creatinine kinase was significantly associated only with severe gestational hypertension diagnosed before 34 weeks of gestation (odds ratio, 9.16, 1.32–63.86; p=0.025) per 1-unit logCK activity. No association was found with pre-eclampsia and HELLP syndrome.

To determine whether plasma creatine kinase activity is similarly associated with blood pressure during pregnancy, the investigators analysed women who participated in the Amsterdam Born Children and their Development Study.

Multiple linear regression and logistic regression models were used to evaluate the association of plasma creatinine activity with blood pressure measurements during pregnancy and with hypertensive disorders in pregnancy (ie, gestational hypertension, HELLP syndrome, pre-eclampsia and eclampsia).

“Hypertensive disorders in pregnancy pose a major burden during pregnancy and are also associated with an increased risk for hypertension later in life,” the investigators said. “Plasma creatine kinase activity is identified in the general population as an independent risk factor for hypertension.”

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Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 19 Feb 2020
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.