Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Creatinine-cystatin C ratio may be indicative of handgrip strength in adults

03 Sep 2020

The creatinine-cystatin C ratio (Cr/CysC) correlates well with handgrip strength and may be useful as a screening tool for middle-aged and elderly adults with low handgrip strength, a recent China study has found.

Researchers conducted a cross-sectional analysis of 2,339 community-dwelling adults (mean age, 55±17 years; 1,241 women). Handgrip strength was measured using a digital grip dynamometer, as administered by training nurses, and serum Cr and CysC were measured using the appropriate assays from blood samples.

Handgrip strength was positively and significantly associated with Cr/CysC in both men (r, 0.376; p<0.001) and women (r, 0.407; p<0.001). Haemoglobin and albumin were also positive correlates, while age and C-reactive protein levels were inverse interactors.

Logistic regression analysis showed that Cr/CysC was significantly indicative of low handgrip strength, as assessed by the Asian Working Group for Sarcopoenia (AWGS) in both men (odds ratio [OR] per 1 standard deviation [SD], 0.63, 95 percent confidence interval [CI], 0.42–0.94) and women (OR per 1 SD, 0.52, 95 percent CI, 0.39–0.69).

A similar pattern of interaction was observed when low handgrip strength was defined according to the European Working Group on Sarcopenia in Older Adults criteria.

At a cutoff of <8.9 in men and <8.0 in women, Cr/CysC had an area under the curve of 0.79 and 0.78, respectively, for the identification of AWGS-defined low handgrip strength.

“In China, community-dwelling older adults have an opportunity to receive a yearly check-up (including the test of Cr and CysC) without charge. Therefore, the Cr/ CysC ratio may be helpful to detect low muscle strength in this population without adding any time-consuming steps, medical device, or financial burden,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
3 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.