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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
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CPX-351 a promising candidate for secondary acute myeloid leukaemia in seniors

17 Nov 2020

CPX-351, a liposomal encapsulation of cytarabine and daunorubicin, is safe and effective in elderly patients with secondary acute myeloid leukaemia (sAML), leading to remission and improving patient response to allogeneic stem cell transplantation (HSCT), a recent study has found.

Seventy-one elderly sAML patients (median age, 66 years; 54.9 percent male) participated in the study and were given CPX-351 as part of a compassionate use programme. Outcomes included treatment response and the incidence of adverse events.

While all 71 patients were able to receive the initial induction of CPX-351, three died before response assessment, leaving 68 available for further therapy and analysis. A total of 20 patients eventually received HSCT.

After a median of 36 days after the initial induction of CPX-351, 53.5 percent of the patients showed complete response. By the end of CPX treatment 70.4 percent of the participants were in complete remission, while 8.5 percent and 14.1 percent showed partial response or were refractory, respectively.

Ten patients relapsed over a median duration of 11 months, and the 12-month cumulative incidence of relapse was calculated to be 23.6 percent. Notably, competing risk analysis showed that CIR dropped when consolidation therapy with HSCT was conducted after CPX-351 (p=0.012).

A total of 21 patients died, including five whose causes of death were treatment-related. Refractory disease was the most common reason for death. The resulting 12-month overall survival rate was 68.6 percent, and the median was not reached. As with the incidence or relapse, HSCT following CPX-351 was a significant predictor of longer survival (p=0.011).

“CPX-351 can induce good quality remissions with acceptable toxicity in the majority of patients, and increases results of HSCT, through a reduction of transplant-related mortality and post-transplant relapse rate,” the researchers said. Further efforts are needed to identify factors affecting treatment response and to investigate the efficacy of CPX-351 in combination with other agents.

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Most Read Articles
10 Jan 2021
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.