Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.

CPAP treatment falls short of improving asthma control in patients with concomitant OSAS

09 Aug 2018

Continuous positive airway pressure (CPAP) treatment offers little benefit to asthmatic patients with obstructive sleep apnoea syndrome (OSAS), with a recent study showing that the intervention does not improve asthma control.

On the other hand, CPAP may attenuate daytime sleepiness, as well as enhance asthma-related quality of life and vitality.

A total of 122 patients with nocturnal asthma symptoms despite treatment with at least moderate‐dose inhaled corticosteroid and long‐acting bronchodilators underwent a home sleep study using a portable diagnostic system. Forty-one patients (33.6 percent) were found to have significant OSAS (apnoea–hypopnoea index [AHI] ≥10/h), among whom 37 were randomized to receive either CPAP (n=17) or conservative treatment (n=20) for 3 months.

Relative to those who did not have the sleep apnoea, OSAS patients had higher body mass index (mean, 27.4 vs 25.1 kg/m2; p=0.016), bigger neck circumference (mean, 36.6 vs 34.8 cm; p=0.006) and lower minimum SaO2 (mean, 80.7 vs 87.2 percent; p<0.001).

CPAP treatment did not produce a significant change in Asthma Control Test score compared with conservative treatment (mean, 3.2 vs 2.4; p=0.568) at month 3. However, CPAP-treated patients showed notable improvements in Epworth Sleepiness Scale (mean, −3.0 vs 0.5; p=0.014), Asthma Quality of Life Questionnaire (mean, 0.6 vs 0.02; p=0.022) and SF‐36 questionnaire vitality domain (mean, 14.7 vs 0.3; p=0.012) scores.

Characterized by repetitive episodes of upper airway obstruction, OSAS has been reported to be highly prevalent in asthmatic populations. The sleep apnoea causes intermittent hypoxia, sleep fragmentation, impaired cognitive function and poor health status. [Thorax 2004;59:618-622; J Thorac Dis 2017;9:1945-1958]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 2 days ago

A subgroup of patients with HBeAg-negative chronic hepatitis B virus (HBV) infection who ceased their long-term nucleotide analogue treatment maintained virological suppression, pointing to a group of patients who may be suitable for treatment cessation, according to a recent study.

Rachel Soon, 4 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

3 days ago
Higher cancer symptom burden in elderly adults is associated with functional impairment, reports a recent study.
Jairia Dela Cruz, 6 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.