Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 2 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 3 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.

CPAP reduces augmentation index, left ventricular workload in healthy males

06 Feb 2018

In healthy young males, continuous positive airway pressure (CPAP) acutely reduces augmentation index (AIx), left ventricular workload and heart rate, a recent study has shown.

Radial artery tonometry was used to measure increased resting and CPAP AIx and central blood pressure parameters in 17 healthy males (mean age 32±16 years). AIx was significantly reduced from baseline (103±10 percent) after CPAP at 5 mbar (97±11 percent (p<0.01) and 10 mbar (95±11 percent; p<0.01). Values significantly increased to 100±10 percent during the recovery phase (p<0.01).

Heart rate likewise showed a significant decline after CPAP at 5 and 10 mbar (64±8 bpm at baseline vs 61±10 and 61±8 bpm, respectively; p=0.02 and p<0.01). The increase during the recovery phase was not significant (63±8 bpm; p=0.37).

CPAP also significantly affected pressure-time integral and performance. For instance, using systolic time integral (2,115±231 mm Hg/s per minute at baseline) as a marker, the researchers observed declines in left ventricular workload after 5 mbar (1,978±290 mm Hg/s per minute; p=0.02) and 10 mbar (1,940±218 mm Hg/s per minute; p<0.001) of CPAP.

Ejection duration was also significantly decreased from baseline after 5 and 10 mbar of CPAP (35±3 vs 33±3 and 32±3, respectively; p=0.02 and p<0.01). No significant recovery effect was observed.

In contrast, the subendocardial viability ratio, as represented by the Buckberg Index, increased following CPAP. From 164±28 percent at baseline, the Index scores rose to 182±32 and 186±23 percent (p<0.001 for both) after 5 and 10 mbar of CPAP, respectively.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 2 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 3 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.