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CPAP reduces augmentation index, left ventricular workload in healthy males

06 Feb 2018

In healthy young males, continuous positive airway pressure (CPAP) acutely reduces augmentation index (AIx), left ventricular workload and heart rate, a recent study has shown.

Radial artery tonometry was used to measure increased resting and CPAP AIx and central blood pressure parameters in 17 healthy males (mean age 32±16 years). AIx was significantly reduced from baseline (103±10 percent) after CPAP at 5 mbar (97±11 percent (p<0.01) and 10 mbar (95±11 percent; p<0.01). Values significantly increased to 100±10 percent during the recovery phase (p<0.01).

Heart rate likewise showed a significant decline after CPAP at 5 and 10 mbar (64±8 bpm at baseline vs 61±10 and 61±8 bpm, respectively; p=0.02 and p<0.01). The increase during the recovery phase was not significant (63±8 bpm; p=0.37).

CPAP also significantly affected pressure-time integral and performance. For instance, using systolic time integral (2,115±231 mm Hg/s per minute at baseline) as a marker, the researchers observed declines in left ventricular workload after 5 mbar (1,978±290 mm Hg/s per minute; p=0.02) and 10 mbar (1,940±218 mm Hg/s per minute; p<0.001) of CPAP.

Ejection duration was also significantly decreased from baseline after 5 and 10 mbar of CPAP (35±3 vs 33±3 and 32±3, respectively; p=0.02 and p<0.01). No significant recovery effect was observed.

In contrast, the subendocardial viability ratio, as represented by the Buckberg Index, increased following CPAP. From 164±28 percent at baseline, the Index scores rose to 182±32 and 186±23 percent (p<0.001 for both) after 5 and 10 mbar of CPAP, respectively.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.