Most Read Articles
11 Oct 2018
Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.
4 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
Pearl Toh, 5 days ago

The duration of dual antiplatelet therapy (DAPT) should be individualized based on ischaemic and bleeding risk of a particular patient, rather than focusing on a dualistic short- vs long-duration therapy thinking, advocates a leading expert during AFCC 2018.

07 Oct 2018
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.

CPAP reduces augmentation index, left ventricular workload in healthy males

06 Feb 2018

In healthy young males, continuous positive airway pressure (CPAP) acutely reduces augmentation index (AIx), left ventricular workload and heart rate, a recent study has shown.

Radial artery tonometry was used to measure increased resting and CPAP AIx and central blood pressure parameters in 17 healthy males (mean age 32±16 years). AIx was significantly reduced from baseline (103±10 percent) after CPAP at 5 mbar (97±11 percent (p<0.01) and 10 mbar (95±11 percent; p<0.01). Values significantly increased to 100±10 percent during the recovery phase (p<0.01).

Heart rate likewise showed a significant decline after CPAP at 5 and 10 mbar (64±8 bpm at baseline vs 61±10 and 61±8 bpm, respectively; p=0.02 and p<0.01). The increase during the recovery phase was not significant (63±8 bpm; p=0.37).

CPAP also significantly affected pressure-time integral and performance. For instance, using systolic time integral (2,115±231 mm Hg/s per minute at baseline) as a marker, the researchers observed declines in left ventricular workload after 5 mbar (1,978±290 mm Hg/s per minute; p=0.02) and 10 mbar (1,940±218 mm Hg/s per minute; p<0.001) of CPAP.

Ejection duration was also significantly decreased from baseline after 5 and 10 mbar of CPAP (35±3 vs 33±3 and 32±3, respectively; p=0.02 and p<0.01). No significant recovery effect was observed.

In contrast, the subendocardial viability ratio, as represented by the Buckberg Index, increased following CPAP. From 164±28 percent at baseline, the Index scores rose to 182±32 and 186±23 percent (p<0.001 for both) after 5 and 10 mbar of CPAP, respectively.

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Most Read Articles
11 Oct 2018
Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.
4 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
Pearl Toh, 5 days ago

The duration of dual antiplatelet therapy (DAPT) should be individualized based on ischaemic and bleeding risk of a particular patient, rather than focusing on a dualistic short- vs long-duration therapy thinking, advocates a leading expert during AFCC 2018.

07 Oct 2018
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.