Most Read Articles
Roshini Claire Anthony, 4 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

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CPAP reduces augmentation index, left ventricular workload in healthy males

06 Feb 2018

In healthy young males, continuous positive airway pressure (CPAP) acutely reduces augmentation index (AIx), left ventricular workload and heart rate, a recent study has shown.

Radial artery tonometry was used to measure increased resting and CPAP AIx and central blood pressure parameters in 17 healthy males (mean age 32±16 years). AIx was significantly reduced from baseline (103±10 percent) after CPAP at 5 mbar (97±11 percent (p<0.01) and 10 mbar (95±11 percent; p<0.01). Values significantly increased to 100±10 percent during the recovery phase (p<0.01).

Heart rate likewise showed a significant decline after CPAP at 5 and 10 mbar (64±8 bpm at baseline vs 61±10 and 61±8 bpm, respectively; p=0.02 and p<0.01). The increase during the recovery phase was not significant (63±8 bpm; p=0.37).

CPAP also significantly affected pressure-time integral and performance. For instance, using systolic time integral (2,115±231 mm Hg/s per minute at baseline) as a marker, the researchers observed declines in left ventricular workload after 5 mbar (1,978±290 mm Hg/s per minute; p=0.02) and 10 mbar (1,940±218 mm Hg/s per minute; p<0.001) of CPAP.

Ejection duration was also significantly decreased from baseline after 5 and 10 mbar of CPAP (35±3 vs 33±3 and 32±3, respectively; p=0.02 and p<0.01). No significant recovery effect was observed.

In contrast, the subendocardial viability ratio, as represented by the Buckberg Index, increased following CPAP. From 164±28 percent at baseline, the Index scores rose to 182±32 and 186±23 percent (p<0.001 for both) after 5 and 10 mbar of CPAP, respectively.

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
3 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
4 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.