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Roshini Claire Anthony, 5 days ago

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CPAP attenuates severity of nonalcoholic fatty liver disease in children

02 Jul 2018

Treating sleep apnoea/nocturnal hypoxia in children using continuous positive airway pressure (CPAP) appears to improve the severity of nonalcoholic fatty liver disease (NAFLD), according to a recent study.

Researchers recruited nine paediatric patients with biopsy-confirmed NAFLD and obstructive sleep apnoea/nocturnal hypoxia. Blood samples were collected to measure concentrations of serum markers of NAFLD severity.

Participants were treated with CPAP for an average duration of 89±62 days with a mean usage per day of 296±126 minutes. The overall adherence was 73±24 percent. As expected, CPAP significantly improved total sleep time (p=0.002), the apnoea-hypopnoea index (p=0.03) and oxygen nadir (p=0.03). Mean scores in the Paediatric Daytime Sleepiness Scale did not significantly change.

Following CPAP treatment, significant improvements in biomarkers of liver injury were observed. For instance, the mean concentration of serum alanine aminotransferase significantly decreased (91±29 to 69±19 IU/L; p=0.02) while aspartate aminotransferase showed a trend toward improvement (60±17 to 51±12 IU/L; p=0.2).

Changes in serum biomarkers were not attributable to a reduction in body mass index, which increased significantly after CPAP (29.5±2.9 to 31.1±3.0 kg/m2; p=0.048).

There was likewise a significant drop in the mean concentrations of adiponectin (7.7±2.4 to 6.1±2.2; p=0.006) and urine F(2)-isoprostanes normalized to urine creatinine (654±191 to 352±157; p=0.02).

“These results further implicate obstructive sleep apnoea as a trigger of oxidative stress and injury that may promote the progression of paediatric [nonalcoholic steatohepatitis]. Therefore, treatment with CPAP may be a potential therapy for preventing the progression of NAFLD,” said researchers.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.