Most Read Articles
16 Jan 2017
There are various ear, nose, and throat (ENT) conditions which present to the GP’s clinic. Dr Jason Hwang, an ENT Consultant from the Department of Otolaryngology at Gleneagles Hospital in Singapore, speaks on how the majority of the conditions can be effectively managed at the primary care level seeing that these can be treated medically without the need for surgical intervention.
16 Dec 2016
Two of the most common hospital-acquired, ventilator-associated nonfermentative gram-negative pneumonia pathogens—Acinetobacter baumannii and Pseudomonas aeruginosa—develop significant resistance to most therapeutic options available, and they should be managed with combination therapies until new antimicrobial agents are developed, according to a study.
24 May 2018
In children and adolescents with cystic fibrosis (CF), synbiotic supplementation appears to be effective at reducing proinflammatory markers such as interleukin (IL)-6 and -8, and nitric oxide metabolites (NOx), a recent study has found.
15 Apr 2018
The use of transbronchial lung biopsy (TBLB) appears to be safe and effective for the pathological diagnosis of lymphangioleiomyomatosis (LAM), suggests a recent study.

CPAP attenuates severity of nonalcoholic fatty liver disease in children

02 Jul 2018

Treating sleep apnoea/nocturnal hypoxia in children using continuous positive airway pressure (CPAP) appears to improve the severity of nonalcoholic fatty liver disease (NAFLD), according to a recent study.

Researchers recruited nine paediatric patients with biopsy-confirmed NAFLD and obstructive sleep apnoea/nocturnal hypoxia. Blood samples were collected to measure concentrations of serum markers of NAFLD severity.

Participants were treated with CPAP for an average duration of 89±62 days with a mean usage per day of 296±126 minutes. The overall adherence was 73±24 percent. As expected, CPAP significantly improved total sleep time (p=0.002), the apnoea-hypopnoea index (p=0.03) and oxygen nadir (p=0.03). Mean scores in the Paediatric Daytime Sleepiness Scale did not significantly change.

Following CPAP treatment, significant improvements in biomarkers of liver injury were observed. For instance, the mean concentration of serum alanine aminotransferase significantly decreased (91±29 to 69±19 IU/L; p=0.02) while aspartate aminotransferase showed a trend toward improvement (60±17 to 51±12 IU/L; p=0.2).

Changes in serum biomarkers were not attributable to a reduction in body mass index, which increased significantly after CPAP (29.5±2.9 to 31.1±3.0 kg/m2; p=0.048).

There was likewise a significant drop in the mean concentrations of adiponectin (7.7±2.4 to 6.1±2.2; p=0.006) and urine F(2)-isoprostanes normalized to urine creatinine (654±191 to 352±157; p=0.02).

“These results further implicate obstructive sleep apnoea as a trigger of oxidative stress and injury that may promote the progression of paediatric [nonalcoholic steatohepatitis]. Therefore, treatment with CPAP may be a potential therapy for preventing the progression of NAFLD,” said researchers.

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Most Read Articles
16 Jan 2017
There are various ear, nose, and throat (ENT) conditions which present to the GP’s clinic. Dr Jason Hwang, an ENT Consultant from the Department of Otolaryngology at Gleneagles Hospital in Singapore, speaks on how the majority of the conditions can be effectively managed at the primary care level seeing that these can be treated medically without the need for surgical intervention.
16 Dec 2016
Two of the most common hospital-acquired, ventilator-associated nonfermentative gram-negative pneumonia pathogens—Acinetobacter baumannii and Pseudomonas aeruginosa—develop significant resistance to most therapeutic options available, and they should be managed with combination therapies until new antimicrobial agents are developed, according to a study.
24 May 2018
In children and adolescents with cystic fibrosis (CF), synbiotic supplementation appears to be effective at reducing proinflammatory markers such as interleukin (IL)-6 and -8, and nitric oxide metabolites (NOx), a recent study has found.
15 Apr 2018
The use of transbronchial lung biopsy (TBLB) appears to be safe and effective for the pathological diagnosis of lymphangioleiomyomatosis (LAM), suggests a recent study.