Most Read Articles
Rachel Soon, 16 Mar 2018

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.

30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.
13 Feb 2018
Short-term treatment with methotrexate at >0.5 defined daily dose (8.75 mg/week) may help reduce the risk of ischaemic stroke in rheumatoid arthritis (RA) patients, while hydroxychloroquine and sulfasalazine have neutral effects, a retrospective study has found.

Could salbutamol be repurposed for treatment of Parkinson’s disease?

15 Nov 2017

The β2‑adrenoreceptor (β2AR) agonist salbutamol, a brain-penetrant asthma medication, appears to reduce the risk of developing Parkinson’s disease (PD), possibly through the epigenetic suppression of SNCA—the gene that encodes α-synuclein, according to a study.

Given that high expression of the SNCA is a risk factor for PD, researchers hypothesized that chemical compounds designed to reduce the transcription of the SNCA gene could prevent or slow down the disease process in selected patients.

To test the hypothesis, researchers went on to assay the relative endogenous SNCA mRNA expression using an unbiased screen targeting endogenous gene expression and found that the β2AR was a regulator of the SNCA.

Next, they examined the pharmaceutical history of more than 4 million Norwegians over an 11-year period. The β2AR agonist salbutamol showed a protective effect against the risk of developing PD (rate ratio, 0.66; 95 percent CI, 0.58 to 0.76). In contrast, a β2AR antagonist was associated with increased PD risk.

Furthermore, β2AR agonist treatment led to SNCA expression reductions in a mouse model of PD and in PD patient-derived cells.

“Our study presents a path to drug development that is distinct from traditional approaches,” researchers said, adding that targeting the endogenous expression of a human disease gene represents a useful strategy for other diseases attributed to copy number variation or regulatory variants.

“Evaluation in additional populations and in clinical trials will be required to determine whether the insights gained in this work can be translated to patients with PD,” they pointed out.

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Most Read Articles
Rachel Soon, 16 Mar 2018

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.

30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.
13 Feb 2018
Short-term treatment with methotrexate at >0.5 defined daily dose (8.75 mg/week) may help reduce the risk of ischaemic stroke in rheumatoid arthritis (RA) patients, while hydroxychloroquine and sulfasalazine have neutral effects, a retrospective study has found.