Most Read Articles
24 Jun 2015
Persistent sleepless nights can take their toll on sufferers, and leave some insomniacs gasping for a caffeine hit just to get them through the morning slog.
01 Aug 2012

Proper use of family planning methods is the key to preventing unplanned preg­nancies. Despite the great effort spent in the research and development of contra­ceptive methods resulting in many new advances, none of the current methods is 100% effective. Emergency contraception (EC), also called ‘postcoital contraception’, is a back-up contraception adminis­tered to a woman after unprotected sexual intercourse (UPSI) or contraceptive failure, so as to prevent unplanned pregnancy. This may be indicated when unexpected intercourse has occurred without the use of any contraception, when there is a sus­pected potential failure of one’s regular contraceptive method (eg, condom break­age or slippage, missed dose of hormonal contraceptive, or potential failure of an intrauterine contraceptive device), or after sexual assault.

Roshini Claire Anthony, 27 Dec 2017

A once-daily subcutaneous dose of teriparatide may be more effective than once-weekly oral risedronate in preventing vertebral fractures in post-menopausal women with osteoporosis and a history of vertebral fractures, findings from the VERO* trial show.

Yesterday
Several adults who experienced a first-time myocardial infarction (MI) at a young age have been found to be ineligible for statin therapy based on current guideline-based treatment thresholds, reports a study, stressing the need for better risk assessment tools among young adults.

Could salbutamol be repurposed for treatment of Parkinson’s disease?

15 Nov 2017

The β2‑adrenoreceptor (β2AR) agonist salbutamol, a brain-penetrant asthma medication, appears to reduce the risk of developing Parkinson’s disease (PD), possibly through the epigenetic suppression of SNCA—the gene that encodes α-synuclein, according to a study.

Given that high expression of the SNCA is a risk factor for PD, researchers hypothesized that chemical compounds designed to reduce the transcription of the SNCA gene could prevent or slow down the disease process in selected patients.

To test the hypothesis, researchers went on to assay the relative endogenous SNCA mRNA expression using an unbiased screen targeting endogenous gene expression and found that the β2AR was a regulator of the SNCA.

Next, they examined the pharmaceutical history of more than 4 million Norwegians over an 11-year period. The β2AR agonist salbutamol showed a protective effect against the risk of developing PD (rate ratio, 0.66; 95 percent CI, 0.58 to 0.76). In contrast, a β2AR antagonist was associated with increased PD risk.

Furthermore, β2AR agonist treatment led to SNCA expression reductions in a mouse model of PD and in PD patient-derived cells.

“Our study presents a path to drug development that is distinct from traditional approaches,” researchers said, adding that targeting the endogenous expression of a human disease gene represents a useful strategy for other diseases attributed to copy number variation or regulatory variants.

“Evaluation in additional populations and in clinical trials will be required to determine whether the insights gained in this work can be translated to patients with PD,” they pointed out.

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Most Read Articles
24 Jun 2015
Persistent sleepless nights can take their toll on sufferers, and leave some insomniacs gasping for a caffeine hit just to get them through the morning slog.
01 Aug 2012

Proper use of family planning methods is the key to preventing unplanned preg­nancies. Despite the great effort spent in the research and development of contra­ceptive methods resulting in many new advances, none of the current methods is 100% effective. Emergency contraception (EC), also called ‘postcoital contraception’, is a back-up contraception adminis­tered to a woman after unprotected sexual intercourse (UPSI) or contraceptive failure, so as to prevent unplanned pregnancy. This may be indicated when unexpected intercourse has occurred without the use of any contraception, when there is a sus­pected potential failure of one’s regular contraceptive method (eg, condom break­age or slippage, missed dose of hormonal contraceptive, or potential failure of an intrauterine contraceptive device), or after sexual assault.

Roshini Claire Anthony, 27 Dec 2017

A once-daily subcutaneous dose of teriparatide may be more effective than once-weekly oral risedronate in preventing vertebral fractures in post-menopausal women with osteoporosis and a history of vertebral fractures, findings from the VERO* trial show.

Yesterday
Several adults who experienced a first-time myocardial infarction (MI) at a young age have been found to be ineligible for statin therapy based on current guideline-based treatment thresholds, reports a study, stressing the need for better risk assessment tools among young adults.