Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Corticosteroids with moxifloxacin effective against ACC with SLE

03 Aug 2017

Corticosteroids combined with the antibiotic moxifloxacin may be effective for the management of acute acalculous cholecystitis (AAC) with systemic lupus erythematosus (SLE), suggests a new observational study.

The investigators recruited 22 AAC patients with SLE who were receiving conservative management of either moxifloxacin alone (n=10; mean age 36.1±16.3 years) or in combination with corticosteroids (n=12; mean age 34.7±11.0 years). Study outcomes included improvement of symptoms and biochemical results, disease response and surgery.

The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2000) scores were significantly lower in the corticosteroid group than in the antibiotic alone group (7.3±1.4 vs 10.7±3.0; p=0.03). A similar trend was observed with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR) scores (0.1±0.3 vs 0.3±0.5; p=0.01).

The levels of antinuclear antibodies (1.3±0.4 vs 2.1±0.6 IU/mL; p=0.03), antidouble stranded DNA antibodies (40.0±8.3 vs 145.4±25.5 IU/mL; p=0.04) and anticardiolipin antibodies (17.9±4.5 vs 46.8±13.7 IU/mL; p=0.01) were significantly lower in the corticosteroid group than in the antibiotic group.

Significantly more patients in the corticosteroid group showed a positive response (p=0.01) and 11 of 12 patients were treated successfully. Only one patient in the corticosteroid group underwent cholecystectomy after treatment yielded no improvements.

By comparison, only four of 10 patients in the antibiotic alone group were successfully treated, and the remaining six had to undergo cholecystectomy because treatment conferred no improvements.

The rate of successful conservative treatment was thus significantly greater in the corticosteroid group than in the antibiotic group (p=0.02).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 2 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 5 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Jairia Dela Cruz, 6 days ago
Male smokers under the age of 50 years are at risk of developing ischaemic stroke, and this risk increases with the number of cigarettes smoked daily, according to data from the Stroke Prevention in Young Men Study.
Yesterday
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.