Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Corticosteroids plus IVIg may lower death risk in patients with SJS/TEN overlap

09 Feb 2021
Xander was diagnosed with Stevens-Johnson syndrome, a life-threatening skin condition in which cell death causes the skin layers to separate. Photo credit: PA REAL LIFE/ The Sun UK

Treatment with corticosteroids in combination with intravenous immunoglobulin (IVIg) is associated with a reduction in mortality risk among patients with Stevens-Johnson syndrome (SLS) and toxic epidermal necrolysis (TEN) overlap and TEN, a recent study has shown.

“Various systemic immunomodulating therapies have been used to treat TEN, but their efficacy remains unclear,” the investigators said.

A systematic review and network meta-analysis was carried out to assess the effects of systemic immunomodulating therapies on mortality for SJS/TEN overlap and TEN. Online databases were searched from inception to 31 October 2019. Mortality rates and Score of Toxic Epidermal Necrolysis (SCORTEN)-based standardized mortality ratio (SMR) were the primary outcomes. Finally, a frequentist random-effects model was adopted.

Sixty-seven studies involving 2,079 patients met the eligibility criteria. A network meta-analysis of 10 treatments demonstrated that none was superior to supportive care in reducing the rates of death and that thalidomide correlated with a significantly higher mortality rate (odds ratio, 11.67, 95 percent confidence interval [CI], 1.42–95.96).

For SMR, a network meta-analysis of 11 treatment arms revealed that the combination therapy of corticosteroids and IVIg was the only treatment associated with significant survival benefits (SMR, 0.53, 95 percent CI, 0.31–0.93).

“Cyclosporine and etanercept are promising therapies, but more studies are required to provide clearer evidence,” the investigators said.

The study was limited by heterogeneity and a small number of eligible randomized controlled trials.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.