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Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

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Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
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Coronary 18F-NaF uptake predicts myocardial infarction in CAD patients

25 Jun 2020

Coronary 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) strongly predicts fatal or nonfatal myocardial infarction in patients with established coronary artery disease (CAD), suggests a recent study.

Patients with known CAD underwent 18F-NaF PET computed tomography and were followed over 42 months (interquartile range, 31–49 months) for fatal or nonfatal myocardial infarction. The coronary microcalcification activity (CMA) determined the total coronary 18F-NaF uptake.

The authors conducted a posthoc analysis of data collected for prospective observational studies. A total of 293 participants (mean age, 65 years; 84 percent men) were included, of whom 203 (69 percent) showed increased coronary 18F-NaF activity (CMA >0). Only those with increased coronary 18F-NaF activity experienced fatal or nonfatal myocardial infarction (20 of 203 with CMA >0 vs 0 of 90 with CMA of 0; p<0.001).

Receiver operator curve analysis showed that 18F-NaF CMA provided the highest prediction of fatal or nonfatal myocardial infarction, besting coronary calcium scoring, modified Duke CAD index, and Reduction of Atherothrombosis for Continued Health (REACH) and Secondary Manifestations of Arterial Disease (SMART) risk scores (area under the curve: 0.76 vs 0.54, 0.62, 0.52, and 0.54, respectively; pall<0.001).

Patients with CMA >1.56 were seven times at greater risk of fatal or nonfatal myocardial infarction (hazard ratio, 7.1, 95 percent confidence interval, 2.2–25.1; p=0.003), independent of age, sex, risk factors, segment involvement and coronary calcium scores, presence of coronary stents, coronary stenosis, REACH and SMART scores, the Duke CAD index, and recent myocardial infarction.

“Reliable methods for predicting myocardial infarction in patients with established CAD are lacking,” the authors said. “Coronary 18F-NaF PET provides an assessment of atherosclerosis activity.”

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Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.