Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

3 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Corneal confocal microscopy adequate for DPN detection in T2DM

10 Oct 2020

Corneal confocal microscopy (CCM) may help detect diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM), a recent study has found.

The study included 220 participants, of whom 172 had T2DM, and the other 48 were set as healthy controls. Aside from CCM, the Diabetic Neuropathy Syndrome (DNS), Neurological Deficit Score (NDS), and neuroelectrophysiological and quantitative sensory testing were all also performed for DPN assessment.

Relative to controls, the NDS and DNS scores were significantly higher in T2DM patients, as were the warm sensation and vibration perception thresholds. The cold sensation threshold, on the other hand, was lower in T2DM patients (p<0.001 for all). Using the Toronto Diabetic Neuropathy Expert Group recommendation, 100 T2DM patients were identified to have DPN.

CCM parameters differed significantly between DPN and non-DPN participants. For example, mean corneal nerve fibre density (CNFD) was significantly higher among those without DPN (23.27±10.01 vs 17.67±7.95 n/mm2; p<0.001).

Similarly, corneal nerve branch density (CNBD; 37.38±17.76 vs 27.05±12.09 n/mm2; p<0.001) and corneal nerve fibre length (CNFL; 15.69±5.26 vs 12.56±3.80 n/mm2; p<0.001) were both significantly greater in non-DPN T2DM patients.

The researchers then performed receiver operating characteristic curve analysis to assess the value of CCM in diagnosing T2DM. At optimal CNFD, CNBD, and CNFL cut-off values of 22.125, 51.875, and 16.29 n/mm2, the areas under the curve (AUC) were 0.731, 0.7, and 0.27, respectively. CNFD and CNFL both had better sensitivity and specificity.

For DPN, the optimal cut-offs for CNFD, CNBD, and CNFL were 24.68, 39, and 15.315 nn/m2, at which values the AUCs were 0.668, 0.675, and 0.701, respectively.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

3 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.