Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.

Coordinated insulin-meal administration lowers glycaemic fluctuation in hospitalized T2D patients

21 Jul 2020
Patients with type 3c diabetes are more likely to require insulin to help control their blood sugar levels.

A coordinated timing from insulin administration to meal consumption (insulin-meal) results in decreased glycaemic fluctuation among hospitalized patients with type 2 diabetes (T2D), results of a recent study have shown.

The investigators sought to examine the impact of coordinated versus mismatched insulin-meal administration on glycaemic fluctuation and outcomes among hospitalized T2D patients. Eligible participants were those who received at least one dose of insulin as part of sliding scale regimen. The investigators then obtained data such as capillary blood glucose values and insulin-meal time intervals.

Overall, 215 patients with 840 insulin-meal encounters were included in this study. Of the participants, 206 belonged to the insulin-meal mismatch group and nine to the coordinated insulin-meal administration group.

Mean glycaemic fluctuation was lower in the coordinated insulin-meal administration group compared to the insulin-meal mismatch group (5.6 vs 6.5 mmol/L or 100 vs 117 mg/dL). Encounters with the insulin-meal time interval of 30–45 min (n=172) correlated with the lowest percentage of severe hyperglycaemia occurrences (13 percent) as compared to encounters with time interval of 0–29 min (n=280; 15 percent) and >45 min (n=246; 16 percent).

In a separate opinion, Etie Moghissi from the University of California stressed the importance of frequent and effective glucose monitoring to avoid wide deviations from acceptable glucose levels, “which under a recently promulgated consensus guideline currently range between 140 and 180 mg/dL.” For hospitalized patients, the recommended glucose target is near 140 mg/dL. [Curr Med Res Opin 2010;26:589-598]

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Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.