Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

Controlling multiple risk factors lowers CAD risk in diabetic patients

13 Nov 2019

Achieving multifactorial targets for blood pressure (BP), low-density lipoprotein-cholesterol (LDL-C), HbA1c and current smoking greatly benefits patients with and without diabetes mellitus (DM) and is associated with a reduced risk for coronary artery disease (CAD), a study has shown.

This prospective cohort study used a nationwide claims database of 220,894 individuals in Japan to examine the effects of the number of controlled risk factors among BP, LDL-C, HbA1c and current smoking on subsequent CAD. Risks over a follow-up of 4.8 years were examined using Cox regression.

Of the participants, the largest percentage had two risk factors at target in patients with (39.6 percent) and without DM (36.4 percent). Regardless of the presence of DM, the risks of CAD were two- and fourfold higher among persons who had achieved any one and no target, respectively, as compared to those who had achieved two targets.

Composite control of modifiable risk factors in patients with DM reduced the risk of CAD below that for those without DM with any two targets achieved. On the other hand, the risk of CAD in the DM group with all four risk factors uncontrolled was 9.4 times higher than that in the non-DM group who had achieved two targets.

“These findings show that composite control of modifiable risk factors has a large effect in patients with and without DM,” the authors said. “The effect was sufficient to bring CAD risk in patients with DM below that in the non-DM group who had two targets achieved.”

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.