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Control measures needed in water systems to reduce Legionellae infection

12 Nov 2020

A recent study has shown the effectiveness of control measures in reducing, but not eradicating, the risk of infection with Legionellae, the bacteria that causes the legionnaires disease (LD).

“It is necessary to extend the diagnostics for Legionella infection in hospitalized children with pneumonia, especially in hospitals with colonized water system,” the authors said.

Clinical specimens from 75 hospitalized patients were tested in 2014–2019. Respiratory samples were cultured for Legionella, while urine samples were tested for Legionella urinary antigens. In addition, the microagglutination test was used for serologic testing. Finally, the authors collected water samples in 2015–2019 and processed these according to ISO11731.

In 2014–2015, five Legionella infections were identified in a children’s hospital in Slovakia. Patients had a median age of 15 years, and all were at high risk and hospitalized due to underlying diseases. Moreover, all patients required intensive care and artificial ventilation due to general deterioration and respiratory failure.

The authors isolated Legionella pneumophila from 72 percent of water samples. Administration of chlorine dioxide above 0.3 ppm into the water system significantly reduced Legionella concentration in water samples. Samples taken from outlets with antimicrobial filter installed tested negative for Legionellae.

“LD occurs predominantly in adults and elderly people… It is rare in younger age groups and prone to be reported as healthcare-associated infection with a higher risk of fatal outcome,” the authors said.

“Hospital-acquired LD is mostly associated with a colonized hospital water system,” they added.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
2 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.