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Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Control measures needed in water systems to reduce Legionellae infection

12 Nov 2020

A recent study has shown the effectiveness of control measures in reducing, but not eradicating, the risk of infection with Legionellae, the bacteria that causes the legionnaires disease (LD).

“It is necessary to extend the diagnostics for Legionella infection in hospitalized children with pneumonia, especially in hospitals with colonized water system,” the authors said.

Clinical specimens from 75 hospitalized patients were tested in 2014–2019. Respiratory samples were cultured for Legionella, while urine samples were tested for Legionella urinary antigens. In addition, the microagglutination test was used for serologic testing. Finally, the authors collected water samples in 2015–2019 and processed these according to ISO11731.

In 2014–2015, five Legionella infections were identified in a children’s hospital in Slovakia. Patients had a median age of 15 years, and all were at high risk and hospitalized due to underlying diseases. Moreover, all patients required intensive care and artificial ventilation due to general deterioration and respiratory failure.

The authors isolated Legionella pneumophila from 72 percent of water samples. Administration of chlorine dioxide above 0.3 ppm into the water system significantly reduced Legionella concentration in water samples. Samples taken from outlets with antimicrobial filter installed tested negative for Legionellae.

“LD occurs predominantly in adults and elderly people… It is rare in younger age groups and prone to be reported as healthcare-associated infection with a higher risk of fatal outcome,” the authors said.

“Hospital-acquired LD is mostly associated with a colonized hospital water system,” they added.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).