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Jairia Dela Cruz, 05 Dec 2017
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Continued statin therapy after adverse reaction reduces incidence of CV events, death

04 Aug 2017
Other experts stand firm that effectiveness of statins is well proven

Continuation of statin prescriptions even after having an adverse reaction is associated with a lower incidence of mortality and cardiovascular (CV) events, a recent study has found.

Researchers recruited patients (n=28,266) with a presumed adverse reaction to a statin between 2000 and 2011 in a retrospective cohort study to explore the relationship between continued statin therapy (any prescription within 12 months after an adverse reaction) and clinical outcomes.

Information on adverse reactions to statins was obtained from structured electronic medical record data or natural-language processing of narrative provider notes. Time to a CV event (myocardial infarction or stroke) or death was the primary composite outcome.

The text of electronic provider notes provided most of the adverse reactions to statins (81 percent). Of the patients, 19,989 (70.7 percent) continued receiving statin prescriptions after the adverse reaction.

The cumulative incidence of CV events or death was 12.2 percent for patients with continued statin prescriptions vs 13.9 percent for those who stopped receiving statins (difference, 1.7 percent; 95 percent CI, 0.8 to 2.7 percent; p<0.001) 4 years after the presumed adverse event.

Secondary analysis of 7,604 patients who received a different statin after the adverse reaction revealed that 2,014 (26.5 percent) had a documented adverse reaction to the second statin. However, 1,696 (84.2 percent) of these patients continued to receive statin prescriptions.

“The risk of recurrent adverse reactions to statins could not be established for the entire sample,” researchers said, adding that it was also not possible to determine whether patients actually took the statins.

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Most Read Articles
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
19 Dec 2016
The prevalence of ECG for left ventricular hypertrophy (LVH) may vary depending on the criteria used across body mass index (BMI) categories in a low cardiovascular risk cohort, suggests a new study.
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.