Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Continued positive outcomes with Mitraclip post-approval

Pearl Toh
17 May 2018

Transcatheter mitral valve repair with the MitraClip device significantly improves the severity of mitral regurgitation (MR), functional status, and quality of life of patients with MR and who were at prohibitive risk for surgery, according to the MitraClip Post-Approval Study 1 (PAS1) presented at SCAI 2018.

“This is a rigorous, real-world study that includes more data than we’ve seen before,” said lead author Dr James Hermiller of St Vincent Heart Center in Indiana, Indianapolis, US.

“The outcomes were extremely encouraging and reinforce the safety and efficacy of this treatment option in real-world practice. We think it has the potential to be a new standard of care for select patients with mitral valve regurgitation.”

The prospective, multicentre, observational study included 1,998 patients (mean age 79.5 years, 56.5 percent men) in the STS/ACC* TVT** registry who underwent MitraClip procedures. A majority of the patients had degenerative MR (85.3 percent) and 90.2 percent were indicated to have prohibitive risk at baseline, with frailty (49.7 percent) and STS Mitral Valve Repair score of 6 percent (46.5 percent) being the most common reasons prohibiting surgery. [SCAI 2018, abstract III-03]

One year after the procedure, a significantly greater proportion of patients had MR grade 2+ (86.8 percent; p<0.0001) compared with baseline, whereby a majority were in MR grade 3+/4+ (94.7 percent).

Echocardiographic measurements also showed significant improvements in left ventricular volume (-8.5 mL; p=0.201) and dimension (-0.20 cm; p<0.0001) from baseline.

Furthermore, functional status improved remarkably in terms of a gain of 38 metres in the 6-minute walk test distance and a 30-point increase in the KCCQ*** quality-of-life scores.

At 1 year, 83.4 percent were classified as having NYHA Class I/II compared with baseline, whereby 85.6 percent had NYHA*** Class III/IV.

Rates of complications were reported at 1.8 percent for single leaflet device attachment and 0.2 percent for device embolization.

“The results demonstrate the continued safety and effectiveness profile of the MitraClip therapy in the post-approval commercial setting … in this highly comorbid, large real-world cohort,” noted Hermiller and co-authors.

The MitraClip was approved by the US FDA in 2013 for degenerative MR, hence opening up a less invasive option for treating the condition compared with conventional surgery. In addition, more data from ongoing randomized study on MR such as the COAPT## trial are eagerly awaited, which will shed light into the role of MitraClip in functional MR, according to the researchers. 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.