Most Read Articles
Roshini Claire Anthony, 6 days ago

Women who receive a single dose of amoxicillin and clavulanic acid within 6 hours of operative vaginal delivery could significantly reduce their postpartum infection risk, according to the UK-based ANODE* trial.

17 Jun 2019
Podcast: Dr Sara Hurvitz highlights that the addition of ribociclib to endocrine therapy improved overall survival in premenopausal women with HR+, HER2- advanced breast cancer, according to the MONALEESA-7 trial.
Audrey Abella, 05 Jul 2018
The addition of the sodium-glucose cotransporter-2 inhibitor ertugliflozin to metformin improved glycaemic control, body weight, and blood pressure (BP) in patients with inadequately controlled type 2 diabetes (T2D), according to the results of the VERTIS MET* trial presented at ADA 2018.
17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.

Constipation impedes desmopressin treatment success in nocturnal enuresis

13 Jun 2019

Response to desmopressin treatment for nocturnal enuresis (NE) in children appears to be compromised in the presence of constipation, particularly in children with severe enuresis and those prescribed low doses, as reported in a recent study.

The study included 383 paediatric patients (52.7 percent boys) aged 5–15 years, among whom 126 (32.9 percent) had primary NE and 257 (67.1 percent) had secondary NE. About a third of the population had a family history of NE (32.6 percent), and 14 percent of patients presented with constipation.

Severe enuresis was more common among patients with constipation than among nonconstipated controls (94.4 percent vs 72.9 percent; p=0.001). NE severity was significantly correlated to responses to desmopressin treatment (p=0.026).

Patients with constipation had significantly lower complete response rate relative to those without constipation. Of note, there was a significant association seen between constipation and the effectiveness of desmopressin both among monosymptomatic NE or nonmonosymptomatic patients with NE.

Complete response rate was also significantly lower in constipated vs nonconstipated patients in the subgroup of those who received 0.2 mg of desmopressin. On the other hand, constipation showed no significant association with treatment response in subgroups of patients with mild-to-moderate NE and 0.4-mg desmopressin.

More studies on subclassification of enuretic patients with a large sample size are warranted to verify the association between constipation and the effectiveness of desmopressin, researchers said.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Women who receive a single dose of amoxicillin and clavulanic acid within 6 hours of operative vaginal delivery could significantly reduce their postpartum infection risk, according to the UK-based ANODE* trial.

17 Jun 2019
Podcast: Dr Sara Hurvitz highlights that the addition of ribociclib to endocrine therapy improved overall survival in premenopausal women with HR+, HER2- advanced breast cancer, according to the MONALEESA-7 trial.
Audrey Abella, 05 Jul 2018
The addition of the sodium-glucose cotransporter-2 inhibitor ertugliflozin to metformin improved glycaemic control, body weight, and blood pressure (BP) in patients with inadequately controlled type 2 diabetes (T2D), according to the results of the VERTIS MET* trial presented at ADA 2018.
17 Feb 2019
In patients with type 2 diabetes (T2D), sodium-glucose cotransporter 2 (SGLT2) inhibitor monotherapy, particularly canagliflozin, exerts greater effects on weight compared with metformin and dipeptidyl peptidase 4 (DPP-4) inhibitors or gliptins, according to the results of a meta-analysis.