Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.

Conservative oxygen therapy does not confer survival gains in ARDS

19 Apr 2020

A conservative oxygenation strategy, with target partial pressure of arterial oxygen (Pao2) 55–80 mm Hg, during the first 7 days of mechanical ventilation falls short of improving survival at 28 days in patients with acute respiratory distress syndrome (ARDS), a study has shown.

A total of 205 ARDS patients randomized to receive either conservative oxygen therapy (target Pao2, 55–70 mm Hg; oxygen saturation as measured by pulse oximetry [Spo2], 88–92 percent) or liberal oxygen therapy (target Pao2, 90–105 mm Hg; Spo2, ≥96 percent) for 7 days. Both groups used the same mechanical ventilation strategies.

The trial was discontinued prematurely due to safety concerns and a low likelihood of achieving a between-group difference in the primary outcome of death from any cause at 28 days. Four patients who did not meet the eligibility criteria were excluded.

The primary outcome was reported in 34 of 99 patients (34.3 percent) in the conservative-oxygen group and 27 of 102 patients (26.5 percent) in the liberal-oxygen group (difference, 7.8 percentage points, 95 percent confidence interval [CI], −4.8 to 20.6).

By day 90, the number of patients who died increased to 44 (44.4 percent) in the conservative-oxygen group and to 31 (30.4 percent) in the liberal-oxygen group (difference, 14.0 percentage points, 95 percent CI, 0.7–27.2).

There were five mesenteric ischaemic events documented in the conservative-oxygen group.

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Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.