Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Conservative oxygen therapy does not confer survival gains in ARDS

19 Apr 2020

A conservative oxygenation strategy, with target partial pressure of arterial oxygen (Pao2) 55–80 mm Hg, during the first 7 days of mechanical ventilation falls short of improving survival at 28 days in patients with acute respiratory distress syndrome (ARDS), a study has shown.

A total of 205 ARDS patients randomized to receive either conservative oxygen therapy (target Pao2, 55–70 mm Hg; oxygen saturation as measured by pulse oximetry [Spo2], 88–92 percent) or liberal oxygen therapy (target Pao2, 90–105 mm Hg; Spo2, ≥96 percent) for 7 days. Both groups used the same mechanical ventilation strategies.

The trial was discontinued prematurely due to safety concerns and a low likelihood of achieving a between-group difference in the primary outcome of death from any cause at 28 days. Four patients who did not meet the eligibility criteria were excluded.

The primary outcome was reported in 34 of 99 patients (34.3 percent) in the conservative-oxygen group and 27 of 102 patients (26.5 percent) in the liberal-oxygen group (difference, 7.8 percentage points, 95 percent confidence interval [CI], −4.8 to 20.6).

By day 90, the number of patients who died increased to 44 (44.4 percent) in the conservative-oxygen group and to 31 (30.4 percent) in the liberal-oxygen group (difference, 14.0 percentage points, 95 percent CI, 0.7–27.2).

There were five mesenteric ischaemic events documented in the conservative-oxygen group.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.