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Conditions, surgeries tied to decreased gastric acid associated with SIBO diagnosis

23 Jan 2020

Conditions of and surgery causing decreased gastric acid correlate with small intestinal bacterial overgrowth (SIBO) diagnosis by culture, a recent study has shown.

Of the 76 patients included, 37 had SIBO (68 percent coliform; 33 percent upper aerodigestive tract [UAT]) and 39 had none. Conditions (p=0.02) and surgery (p<0.01) related to decreased gastric acid were associated with SIBO.

Multinomial logistic regression revealed an association between conditions of decreased acid and UAT SIBO (odds ratio [OR], 5.8, 95 percent confidence interval [CI], 1.4–33.3). Surgery causing decreased acid correlated with UAT (OR, 9.5, 95 percent CI, 1.4–106) and coliform SIBO (OR, 8.4, 95 percent CI, 1.6–86.4). Coliform SIBO was detected in three patients with discontinuous small bowel (OR, 17.4, 95 percent CI, 1.2–2,515).

No differences were observed in complications, overall symptoms, quality of life or psychological traits.

In this study, small bowel aspirates were cultured in patients with suspected SIBO, defined as ≥104 colony-forming units/mL coliform or ≥105 colony-forming units/mL UAT bacteria. The investigators reviewed patient history for risk factors and potential SIBO complications, and evaluated symptoms, quality of life, psychological traits and laboratory values.

Groups were compared by 2-sample t-test, Wilcoxon rank sum test and the Fisher exact test. Analysis of variance F-test, Kruskal-Wallis test, and the Fisher exact tests was conducted to assess overall associations of primary and secondary endpoints with bacterial overgrowth type. Multinomial logistic regression was performed to examine the associations between risk factors and overgrowth type.

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Most Read Articles
Pearl Toh, 2 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
5 days ago
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