Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 4 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
6 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


Conbercept improves visual acuity in age-related macular degeneration

Jairia Dela Cruz
10 Sep 2018

Administering conbercept at a dose of 0.5 mg once monthly for the first 3 months then once quarterly until month 12 appears to be effective in the treatment of age-related macular degeneration (AMD), with significant improvements in visual acuity observed at month 3 and maintained through 1 year, according to the results of the phase III PHOENIX trial.

“Because other anti-VEGF [vascular endothelial growth factor] agents cannot support [the said] dosing regimen, treatment using conbercept has the potential to be a more patient-friendly treatment than are existing treatments,” the authors said.

PHOENIX randomized 124 patients (aged ≥50 years) with active, primary or recurrent subfoveal or juxtafoveal choroidal neovascularization (CNV) secondary to AMD to receive either conbercept (n=81) or sham injection (n=43). The dosing regimen used was as follows: three sequential monthly injections, with additional injections given once every 3 months until month 12.

Efficacy and safety were assessed in 114 patients who completed the 12-month study. At baseline, lesion size was <30 mm2, and best-corrected visual acuity (BCVA) letter scores ranged between 73 (20/40 Snellen equivalent) and 19 (20/400 Snellen equivalent) letters. The primary efficacy endpoint of mean change in BCVA at month 3 was significantly greater with conbercept vs sham (9.20 vs 2.02 letters; p<0.001). [Am J Ophthalmol 2018;doi:10.1016/j.ajo.2018.08.026]

Improvements in BCVA persisted at 12 months, although the changes were not significantly different between the two groups (9.98 vs 8.81 letters; p=0.64).

The study drug was generally well-tolerated. Adverse events (AE), ocular or nonocular, occurred in 40 patients (49.4 percent) in the conbercept group and in 16 (37.2 percent) in the sham group. The most common AEs were injection site haemorrhage and increased intraocular pressure.

There were no reports of cataract, vitreous haemorrhage or serious ocular inflammation (sterile or infectious endophthalmitis) in the study eyes of the conbercept group, nor there were accounts of allergic reactions and deaths.

An anti-VEGF agent developed in China, conbercept successfully improved visual acuity and reduced central retinal thickness and CNV area in patients with neovascular AMD in previous phase I and II studies. [Ophthalmology 2011;118:672-678; Ophthalmology 2014;121:1740-1747]

“While head-to-head studies are still needed, the PHOENIX study shows that conbercept is an effective and well-tolerated treatment for AMD with the potential to provide health outcome advantages over other [drugs of the same class],” the authors noted.

“Since anti-VEGF treatment plays an increasingly important role in treating neovascular ocular diseases, decreasing the treatment frequency and compliance burden would yield considerable social benefits and probably make a difference in promoting vision healthcare,” they added.

The study was limited by an inability to rule out the possibility that some patients in the study sample had polypoidal choroidal vasculopathy.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 4 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
6 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.