Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
6 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Computerized cognitive training improves cognitive function, brain connectivity

19 May 2019

A computerized cognitive training regimen effectively improves global cognition and brain plasticity in patients with vascular cognitive impairment, a recent study has found.

Sixty patients were randomly assigned to receive either the cognitive training regimen (n=30; mean age, 63.9±7.9 years; 40.0 percent female) or to an active control group (n=30; mean age, 64.9±6.6 years; 26.7 percent female). Those assigned to the training underwent a computerized, multidomain and adaptive programme, which lasted for 7 weeks. Domains included problem solving, executive control, calculation, long-term and working memory, processing speed, perception, attention, reasoning, and calculation.

After 7 weeks, there was a significant improvement in Montreal Cognitive Assessment (MoCA) scores in patients who received cognitive training (change from baseline, 3.356; 95 percent CI, 1.467–5.244). No such effect was observed in the active control group (change from baseline, –0.085; –2.062 to 1.892; effect size, 0.637; 0.115–1.153).

This difference did not persist until the 6-month follow-up (training group: change from baseline, 2.224; 0.256–4.192; active control: change from baseline, 1.358; –0.899 to 3.614; effect size, 0.866; –0.361 to 0.653).

Notably, from baseline to the end of the study, researchers also observed a significant increase in the connectivity between the left dorsolateral prefrontal cortex and median prefrontal cortex. This was true for participants who received the cognitive training but not in those who were assigned to the active control.

The improvement in connectivity was likewise significantly and positively associated with changes in MoCA in the training (r, 0.463; p=0.017) but not in the active control (r, 0.08; p=0.68) group.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
6 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.