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Complications after breast reconstruction tied to worse survival, recurrence

20 Aug 2020

Postoperative complications that occur following total mastectomy and immediate reconstruction in breast cancer patients can be a tell-tale sign of poor survival and recurrence, suggests a study.

“Immediate breast reconstruction is safe from an oncological perspective, but the relatively high rate of postoperative complications raises oncological concerns,” the authors said.

To assess the potential impact of postoperative complications on recurrence and survival, patients with breast cancer who had total mastectomy and immediate reconstruction between 2008 and 2013 were followed for at least 5 years. Multivariable Cox regression analyses were performed to examine the influence of postoperative complications on oncological outcomes.

A total of 483 patients with a median follow-up of 82 months were included in the analysis. The corresponding 5-year local recurrence-free, disease-free, and overall survival rates were 95.4 percent, 93.1 percent, and 98.4 percent.

One hundred twenty patients (27.4 percent percent) developed postoperative complications in the operated breast and 30 patients (6.8 percent) at other sites (flap donor). Development of breast complications led to a significant increase in the rate of recurrence as compared with no complications (16.7 percent vs 5.9 percent; p=0.002).

Multivariate analysis revealed a significantly worse disease-free survival among patients with breast complications compared to those with no complications (hazard ratio [HR], 2.25; p=0.015). The significant association between postoperative complications and poor survival persisted in patients who received adjuvant chemotherapy without delay (8 weeks after surgery; HR, 2.45; p=0.034).

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Most Read Articles
2 days ago
High-frequency use of cannabis appears to worsen clinical pain and associated symptoms among chronic pain patients, a recent study has found.
Jairia Dela Cruz, 5 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Yesterday
Women with pre-eclampsia are at higher risk of developing heart failure, a study suggests.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.