Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

Complex congenital heart disease compromises body composition

13 Oct 2019

Adults with complex congenital heart disease (CHD) have lower skeletal muscle mass and are more likely to have sarcopoenia, a recent study has found.

Seventy-three complex CHD patients (mean age, 35.8±14.3 years; 22 females) underwent dual-energy x-ray absorptiometry (DXA) for the measurement of body composition. Those with low skeletal muscle mass in relation to height and weight were identified as sarcopoenic. Seventy-three age- and sex-matched controls were also included.

In the overall sample, complex CHD patients were significantly shorter than their control counterparts (173.2±9.7 vs 176.6±9.2 cm; p=0.029), while also having lower total lean mass (48.3±8.7 vs 53.3±9.6 kg; p=0.001), appendicular lean mass (21.69±4.70 vs 24.95±5.28; p<0.001), and isometric strength of the biceps (p=0.004), quadriceps (p=0.002) and unilateral grip (p=0.002).

Relative tissue fat mass, on the other hand, was significantly elevated in those with complex CHD (31.8±9.3 vs 27.4±8.7 percent; p=0.003).

Analysis according to sex showed that the effect of complex CHD was stronger in females, where almost all anthropometric, DXA and isometric strength domains were significantly worse in patients than in controls. The only exceptions were weight and hip circumference. Male patients were shorter and lighter than controls, and had worse DXA results and isometric strength.

Despite these findings, researchers noted that the both the muscle and fat differences between patients and controls could be made up for by behavioural changes. “Perhaps the next step toward a longer and healthier life for adults with congenital heart disease lies in a more structured follow-up programme promoting individualized training regimen and a healthy diet.”

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.
18 Apr 2020
Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.