Most Read Articles
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.
10 Apr 2019
An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease, successfully replicating microbiome changes elicited by exclusive enteral nutrition and reducing gut inflammation, a recent study has shown.
12 Nov 2018
Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.

Complete endoscopic resection may not be suitable as sole therapy for Barrett’s oesophagus

13 Feb 2018

Complete endoscopic resection (CER) of Barrett’s oesophagus (BE) results in a complete eradication rate of 85 percent, with nearly 6-percent recurrent rate of neoplasia, reports a recent study. Additionally, the estimated rate of postprocedural stricture was 37.4 percent.

A total of eight studies involving 676 patients (high-grade dysplasia, 54 percent) met the inclusion criteria.

The pooled estimated rates were 85.0 percent (95 percent CI, 79.4‒89.2 percent) for complete eradication of intestinal metaplasia and 96.6 percent (94.0‒98.1 percent) for complete eradication of intestinal neoplasia. Recurrence rates of intestinal metaplasia and neoplasia were 15.7 percent (8.0‒28.4 percent) and 5.8 percent (3.9‒8.6 percent), respectively.

Estimated incidences of adverse events were as follows: stricture (37.4 percent; 24.4‒52.6 percent), bleeding (7.9 percent; 4.4‒13.8 percent) and perforation (2.3 percent; 1.3‒4.1 percent).

“On the basis of this high rate of adverse events and significant heterogeneity in the studies included, the present meta-analysis cannot endorse CER as sole therapy for BE,” the investigators said.

To report the rate of eradication and recurrence of both neoplasia and intestinal mucosa, as well as the rate of adverse events for CER of BE, the investigators conducted a systematic review and meta-analysis of cohort studies that reported the clinical outcome of patients with BE who underwent CER and had at least 15-month follow-up after the time of elimination of BE.

Main outcomes included pooled estimated rates of complete eradication of intestinal metaplasia and neoplasia, recurrence of intestinal metaplasia and neoplasia, and incidence of oesophageal stricture, bleeding and perforation.

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Most Read Articles
11 Apr 2019
Cannabis use disorder appears to exert a beneficial effect on the risk of disorders of gut–brain interaction and inflammatory bowel disease in patients with schizophrenia but not in population controls, a study has found. This finding raises the possibility of new targets for treatment and prevention of digestive organ disorders in schizophrenia.
10 Apr 2019
An individualized, food-based diet may be a potential treatment approach for patients with active Crohn’s disease, successfully replicating microbiome changes elicited by exclusive enteral nutrition and reducing gut inflammation, a recent study has shown.
12 Nov 2018
Individuals with severe and frequent gastro-oesophageal reflux disease (GERD) are at increased risk of Barrett’s oesophagus (BE), especially in the absence of frequent proton pump inhibitor (PPI) use, a recent study has found. Family history of BE and early age of symptom onset are strong predictors of BE among people with GERD.